Prof John Terry

Professor of Biomedical Modelling

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Telephone: 01392 725274

Extension: (Streatham) 5274

Director EPSRC Centre for Predictive Modelling in Healthcare, Co-Director Wellcome Trust Centre for Biomedical Modelling and Analysis

Hot off the press! See our new website for the EPSRC Centre for Predictive Modelling in Healthcare.  We are always keen to support applications for Fellowships from talented early career researchers. If you would like to hold a Fellowship within the Centre, please find information about how to do this here.

 

I am Professor of Biomedical Modelling, Director of the EPSRC Centre for Predictive Modelling in Healthcare and Co-Director of the Wellcome Trust ISSF2 Centre for Biomedical Modelling and Analysis. My research is focussed on the development and application of mathematical and computational methodologies for understanding the dynamics of biomedical systems, with particular interests in the transitions between healthy and diseased states in the human brain and also in the dynamics of endocrine systems. Since 2003 I have supervised the research training  and development of 30 individuals, including 12 PhD students.

 

Collectively these Centres involve 14 investigators, employ 15 Postdoctoral Research Fellows, 2 MRC funded independent Fellowship holders and a Research Software Engineer. Additionally we are currently training 11 PhD students. Researchers who I work most closely with are a senior lecturer - Marc Goodfellow, an MRC funded Career Development Award Holder - Jamie Walker, an MRC funded Skills Development Fellow - Wessel Woldman, 6 PDRAs - Leandro Junges, Marinho Lopes, George Petkov, Piotr Slowinski, Margaritis Voliotis and Eder Zavala, a Research Software Engineer - Diane Fraser and 4 PhD students - Rudy Arthur, Zoe Bright, Lauric Ferrat and Harry Green. As a group of over 40 researchers devoted to mathematical and computer science research at the interface with biomedicine and healthcare, we are a significant presence in the UK! If you would like to join us, please find out more here.

Eder Zavala works on modelling the complex gene regulatory network mechanisms of the pituitary and adrenal glands. Leandro Junges works on mathematical models for predicting sites of surgical resection in people undergoing elective brain surgery for epilepsy. Margaritis Voliotis works on mechanisms of endocrine regulation, with a focus on GNRH. Marinho Lopes works on complex networks in epilepsy. George Petkov works on the theory of complex networks to explain neural data. Piotr Slowinski is funded by Epilepsy Research UK to develop models of focal-onset epilepsies. Jamie Walker holds an MRC funded Career Development Award, where he is interested in the multi-level network basis of hormone pulsatility in the HPA-axis, with a particular focus on the pituitary gland. Wessel Woldman support by and MRC Skills Development Fellowship studies dynamic mechanisms of epilepsy and is focussed on the translation of research findings into novel diagnostic and prognostic tools. Diane Fraser is currently developing prototype decision support tools based on our research findings. Harry Green is exploring the use of phenomenological models to understand the mechanisms of cardiac arhythmias. Lauric Ferrat has a background in statistics and will focus on developing methods for enabling the clinical translation of physioloigcally inspired neural-mass models. Zoe Bright joins us from the MSc in Mathematical Biology at York and is working on the interface between stress, the brain and disease, with a focus on epilepsy.

Background


Graduating in Mathematics with 1st class honours from the University of Reading in 1997, I subsequently studied for a PhD in Applied Mathematics jointly between the University of Surrey and the Georgia Institute of Technology. Following postdoctoral positions at the University of Warwick and the University of Queensland, I was appointed Lecturer in Mathematical Sciences at Loughborough University in 2002. From 2006–2010, I was first Lecturer, then Senior Lecturer and finally Reader within the Department of Engineering Mathematics at the University of Bristol. I then moved to a Prize Readership in Theoretical Neuroscience at the University of Sheffield in 2010, before joining the University of Exeter in 2012.


I have a long track-record in multidisciplinary research with scientists in clinical and experimental neuroscience, where I am internationally renowned for systems modelling approaches in neuroscience and endocrinology, in particular applications to epilepsy, Parkinson’s disease and the Hypothalamic-Pituitary-Adrenal axis. Current research includes:


- Characterising the evolution of epilepsies using neural modelling techniques, with the aim to create improved diagnosis techniques for clinicians and to better predict treatment outcomes.


- Developing tools for describing networks of interacting brain regions and characterising seizure initiation based upon network structure.


- Developing models for interpreting the effects of Deep Brain Stimulation with applications to Parkinson’s and Epilepsy.


- Exploring the interactions between neural dynamics and hormone secretions in the Hypothalmic-Pituituary-Adrenal axis; by understanding the mechanisms responsible for fluctuations observed in blood concentrations of steroids, more appropriate treatments for a number of clinical conditions may be developed.

- Developing models of the phenomenology of electrical data recording clinically during radiofrequency ablation therapy for the treatment of cardiac arrhythmias. 


I have authored over 50 publications of original research, as well as a number of conference proceedings. A member of the steering committee of the UK’s Mathematical Neuroscience Network, as well as the UK’s Neuroinformatics Node, I sit on the editorial boards of the Journal of Mathematical Neuroscience and also Nonlinear Biomedical Physics, and have acted as an associate editor for PLoS Computational Biology, as well as guest editor for special issues of Progress in Molecular Biology and Biophysics and the European Journal of Neuroscience. I am a member of the EPSRC peer-review college, as well as a member of the MRCs strategic skills panel. I also act as a reviewer for several mathematics and neuroscience journals.


My research group is or has been funded by the EPSRC, the MRC, the BBSRC, the Leverhulme Trust, the Wellcome Trust and the Royal Society. In total I have held or co-held in excess of £10 million of research funding since 2003. Currently active grants include Centre grant funding from EPSRC, Programme Grants on Epilepsy and HPA function from MRC, Wellcome Trust ISSF2 and ISSF3 awards, and a research project grant from Epilepsy Research UK.


Outside of work I enjoy running where I have at one time or other run for and managed Westbury Harriers and Hermitage Harriers. Recent results are available here. Presently I run unattached.

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