Prof John Terry
Professor in Biomedical Modelling
Telephone: 01392 725274
Extension: (Streatham) 5274
I am Professor of Biomedical Modelling and Academic Lead for the Systems Biomedicine and Control group. My research is focussed on the development and application of mathematical and computational methodologies for understanding the dynamics of biomedical systems, with particular interests in the transitions between healthy and diseased states in the human brain and also in the dynamics of endocrine systems. Since 2003 I have supervised the research training of 22 individuals, including 10 PhD students.
Hot off the press! We have recently received further MRC Programme Grant funding to explore the role of brain networks in the generation of epilepsy. In this regard George Petkov (SEIN, Netherlands) has recently joined the group, alongside a new lecturer Marc Goodfellow who will work with us during the academic year 2013/14. We will also advertise a further Research Associate position related to this grant in due course. There is also funding available for a PhD within the broad area of brain networks and dynamical modelling applied to epilepsy research. I would welcome informal inquiries by email about any of these opportunities, as well as from candidates who might be interested in applying for Fellowship support (deadlines typically April and September) to join our rapidly growing research group.
Rita Gupta (formerly a post-doc at Birmingham) works on modelling the complex gene regulatory network mechanisms of the pituitary and adrenal glands. Helmut Schmidt (PhD at Nottingham) works on an Epilepsy Research UK funded project exploring the use of computer models for predicting treatment responsiveness in patients with generalised epilepsy. Jamie Walker (PhD at Bristol) has commenced his MRC funded Special Training Fellowship in Computational Biology, where he is based primarily in the Laboratories for Integrative Neuroscience and Endocrinology in Bristol.
We organised the first BioDynamics workshop, which took place in Bristol from 11-13 September 2013. Nearly 120 delegates heard from invited plenary speakers including Russell Foster (Oxford), Michael Hastings (Cambridge), David Hazelrigg (Aberdeen), Kevin O'Byrne (King's College London), David Rand (Warwick) and James Sneyd (Auckland).
Graduating in Mathematics with 1st class honours from the University of Reading in 1997, I subsequently studied for a PhD in Applied Mathematics jointly between the University of Surrey and the Georgia Institute of Technology. Following postdoctoral positions at the University of Warwick and the University of Queensland, I was appointed Lecturer in Mathematical Sciences at Loughborough University in 2002. From 2006–2010, I was first Lecturer, then Senior Lecturer and finally Reader within the Department of Engineering Mathematics at the University of Bristol. I then moved to a Prize Readership in Theoretical Neuroscience at the University of Sheffield in 2010, before joining the University of Exeter in 2012.
I have a long track-record in multidisciplinary research with scientists in clinical and experimental neuroscience, where I am internationally renowned for systems modelling approaches in neuroscience and endocrinology, in particular applications to epilepsy, Parkinson’s disease and the Hypothalamic-Pituitary-Adrenal axis. Current research includes:
- Characterising the evolution of epilepsies using neural modelling techniques, with the aim to create improved diagnosis techniques for clinicians and to better predict treatment outcomes.
- Developing tools for describing networks of interacting brain regions and characterising seizure initiation based upon network structure.
- Developing models for interpreting the effects of Deep Brain Stimulation with applications to Parkinson’s and Epilepsy.
- Exploring the interactions between neural dynamics and hormone secretions in the Hypothalmic-Pituituary-Adrenal axis; by understanding the mechanisms responsible for fluctuations observed in blood concentrations of steroids, more appropriate treatments for a number of clinical conditions may be developed.
I have authored over 40 publications of original research, as well as a number of conference proceedings. A member of the steering committee of the UK’s Mathematical Neuroscience Network, as well as the UK’s Neuroinformatics Node, I sit on the editorial board of the Journal of Mathematical Neuroscience, and have acted as an associate editor for PLoS Computational Biology, as well as guest editor for special issues of Progress in Molecular Biology and Biophysics and the European Journal of Neuroscience. I also act as a reviewer for several mathematics and neuroscience journals.
My research group is or has been funded by the EPSRC, the MRC, the BBSRC, the Leverhulme Trust and the Royal Society. In total I have held or co-held in excess of £8 million of research funding since 2003. Currently active grants include Programme Grants on Epilepsy and HPA function from MRC and epilepsy from Epilepsy Research UK.
Outside of work I enjoy running where I have at one time or other run for and managed Westbury Harriers and Hermitage Harriers. Recent results are available here. Presently I run for Exeter Harriers.