Pablo Martinez Pancorbo

PhD Project

Functional, specially-doped Core-shell nanoparticles for biomedical imaging applications

Supervisors: Prof. Yanqiu Zhu and Prof. Nick Stone.

Nanoparticles exhibit unusual properties against their bulk counterparts, and this is where current Bio-imaging research stands using plain nanoparticles. However further modification of the plain forms of nanoparticles will lead to far more exciting multifunctionalities. Apart from the size, the compositional change, geometry modifications and complex systems (Core-Shell) generate new features for the nanoparticles. 

This project built on top of two types of nanoparticle that we have prepared earlier, endeavours to apply new approaches to enhance their functionalities. Firstly, by doping to modify the state of the nanoparticles, making them more sensitive to spectrum/plasma irradiations in biomedical imaging. Secondly, by forming complex core-shell structures towards Surface enhanced Raman responses. Some nanoparticles remains as the Core and others as the inorganic shell. And last but not least, further combination of the doped core-shell will expect far more interesting properties.This project fits the Nanomaterials, Plasmonics, and magnetic materials Themes. We will consider developing collaborative links with industry in NP provision, in biomedical labelling technologies and readout devices. Plain nanoparticles synthesis nowadays is standard; the doping and core-shell are new, but with clear requirement and targets in Bio-imaging could lead to world-leading results on top journals. 

References:

Chem. Mater. 2008, 20, 5657–5665; Nanotechnology 19 (2008) 305709 (7pp)