Dr Michele Gintoli
Postdoctoral Research Fellow
I am currently working as a postdoctoral research fellow in the Biomedical Physics group with Dr Alex Corbett on an EPSRC research grant (EP/R021252/1, "Fast and Flexible Imaging of Excitable Tissues").
The aim of the project is to develop a light sheet microscope in which a pencil of light is rapidly swept back and forth inside the sample, while a detection lens keeps the focus on the illuminated volume, to relay the specimen image back to the camera even when the sweeping direction is tilted.
Previously, to capture two cells within a specimen that are located at different depths, the microscope would capture many images covering the range of depths between the two objects. Much of this information would not be useful. By using a tilted illumination plane, it is possible to capture both cells in a single image, saving on data volume, removing the need of post-processing steps and increasing the overall imaging speed. This last point is particularly useful when trying to measure electrical communication between two cells, which can happen in just a few milliseconds.
My general interest is in the development of optical tools for probing and interacting with matter. This specifically translates into microscopes and laser writing systems.