Monday 07 Mar 2016: Dynamics seminar - Mathematics Arising from Stent Implantation
Prof. Sean McKee - University of Strathclyde
This talk will be concerned with mathematical models of drug-eluting stents. Coronary heart disease, atheroscelerosis, restenosis and the general physiology of coronary arteries will be introduced. The transport mechanisms and the philosophy behind mathematical modelling will be discussed.
An argument will be put forward for why one-dimensional (as opposed to full three-dimensional calculations) can often suffice. Following this , three different models will be discussed in some detail. The first concerns drug-elution from a polymer-coated stent. The second involves an in-vitro experiment to determine the uptake and release parameters for sirolimus to endothelial cells in a petri dish. The third is about drug release from an abraded (bare) metal stent onto which drug has been sprayed.
It is argued that these models can yield useful clinical information.