Dr Marc Goodfellow
Telephone: 01392 723420
Extension: (Streatham) 3420
Office: LSI building 5.10
I am a lecturer in Mathematics, member of the Systems Biomedicine group, affiliate of the Centre for Biomedical Modelling and Analysis and co-investigator of the EPSRC Centre for Predictive Modelling in Healthcare. My research is focussed on the development and use of mathematical and computational methods to help us understand the dynamics of complex biological systems, with a focus on problems in healthcare.
I study diverse biological systems ranging in spatial scales from cells to whole organs. Of particular interest are the dynamics of the brain, which fluctuate to give rise to evolving spatiotemporal patterns that can be significantly altered in disorders such as epilepsy. Using mathematical methods to uncover the mechanisms that govern these differences, and applying this knowledge to improve diagnosis and treatment, is an ongoing focus of my research.
Current group members:
Dr. Petroula Laiou (Research Fellow) employed on EPSRC research grant "Quantifying uncertainty in perturbed brain networks: towards a decision support tool for epilepsy surgery"
Dr Hossein Mohammadi (Research Fellow) employed on EPSRC Centre Grant "Predictive Modelling in Healthcare"
Dr Tanja Zerenner (Research Fellow) employed on EPSRC Centre Grant "Predictive Modelling in Healthcare"
Miss Kathryn Bennett (PhD student, Bristol): Neural networks underlying essential tremor
Mr Joe Pinion (PhD student): The effect of chemoconvulsant drug exposure on neural network activity in the larval zebrafish
Previous group members:
Dr. Lauric Ferrat
Dr Marinho Lopes
Mr. Luke Tait
Dr Leandro Junges
Dr. Piotr Slowinski
Tait, L., Stothart, G., Coulthard, E., Brown, J. T., Kazanina, N., & Goodfellow, M. (2019). Network substrates of cognitive impairment in Alzheimer’s Disease. Clinical Neurophysiology, 130(9), 1581–1595.
Junges, L., Lopes, M. A., Terry, J. R., & Goodfellow, M. (2019). The role that choice of model plays in predictions for epilepsy surgery. Scientific Reports, 9(1), 1–12.
Lopes, M. A., Goodfellow, M., & Terry, J. R. (2019). A Model-Based Assessment of the Seizure Onset Zone Predictive Power to Inform the Epileptogenic Zone. Frontiers in Computational Neuroscience, 13(April), 1–10. (* joint senior author)
Lopes, M. A., Richardson, M. P., Abela, E., Rummel, C., Schindler, K., Goodfellow, M.*, & Terry, J. R.* (2017). An optimal strategy for epilepsy surgery: Disruption of the rich-club? PLoS Comput Biol 13(8): e1005637 (* joint senior author)
Goodfellow, M., Rummel, C., Abela, E., Richardson, M.P., Schindler, K. and Terry, J.R. (2016) Estimation of brain network ictogenicity predicts outcome from epilepsy surgery. Scientific Reports 6: 29215.
Goodfellow M, Phillips NE, Manning C, Galla T, Papalopulu N. (2014) microRNA input into a neural ultradian oscillator controls emergence and timing of alternative cell states, Nat Commun, volume 5,
Goodfellow M, Schindler K, Baier G. (2011) Intermittent spike-wave dynamics in a heterogeneous, spatially extended neural mass model, Neuroimage, volume 55, no. 3, pages 920-932,