Dr Marc Goodfellow
Telephone: 01392 723420
Extension: (Streatham) 3420
Office: LSI building 5.10
I am a lecturer in Mathematics, member of the Systems Biomedicine group, affiliate of the Centre for Biomedical Modelling and Analysis and co-investigator of the EPSRC Centre for Predictive Modelling in Healthcare. My research is focussed on the development and use of mathematical and computational methods to help us understand the dynamics of complex biological systems, with a focus on problems in healthcare.
I study diverse biological systems ranging in spatial scales from cells to whole organs. Of particular interest are the dynamics of the brain, which fluctuate to give rise to evolving spatiotemporal patterns that can be significantly altered in disorders such as epilepsy. Using mathematical methods to uncover the mechanisms that govern these differences, and applying this knowledge to improve diagnosis and treatment, is an ongoing focus of my research.
Current group members:
Dr. Petroula Laiou (Research Fellow) employed on EPSRC research grant "Quantifying uncertainty in perturbed brain networks: towards a decision support tool for epilepsy surgery" (01/09/17 - 01/09/19)
Dr. Piotr Slowinski (Research Fellow) employed on Epilepsy Research UK Grant "An optimal model for focal onset epilepsies" (01/02/16-31/01/19)
Dr Leandro Junges (Research Fellow) employed on EPSRC Centre Grant "Predictive Modelling in Healthcare" (01/09/16-31/08/19).
Dr Hossein Mohammadi (Research Fellow) employed on EPSRC Centre Grant "Predictive Modelling in Healthcare" (01/09/16-31/08/19).
Dr Marinho Lopes (Research Fellow) employed on MRC Programme Grant "Brain Networks in Epilepsy: Endophenotypes and Generative Models" (01/04/15 - 31/03/18)
Mr. Lauric Ferrat (PhD student): statistical approaches to studying the output of dynamical systems with many parameters
Mr. Luke Tait (PhD student): Multi-scale analysis and modelling in dementia
Miss Kathryn Bennett (PhD student, Bristol): Neural networks underlying essential tremor
Mr Joe Pinion (Msc. student): The effect of chemoconvulsant drug exposure on neural network activity in the larval zebrafish
Lopes, M. A., Richardson, M. P., Abela, E., Rummel, C., Schindler, K., Goodfellow, M.*, & Terry, J. R.* (2017). An optimal strategy for epilepsy surgery: Disruption of the rich-club? PLoS Comput Biol 13(8): e1005637 (* joint senior author)
Goodfellow, M., Rummel, C., Abela, E., Richardson, M.P., Schindler, K. and Terry, J.R. (2016) Estimation of brain network ictogenicity predicts outcome from epilepsy surgery. Scientific Reports 6: 29215. doi: 10.1038/srep29215
Goodfellow M, Phillips NE, Manning C, Galla T, Papalopulu N. (2014) microRNA input into a neural ultradian oscillator controls emergence and timing of alternative cell states, Nat Commun, volume 5, DOI:10.1038/ncomms4399.
Petkov G, Goodfellow M, Richardson MP, Terry JR. (2014) A critical role for network structure in seizure onset: a computational modeling approach, Front Neurol, volume 5, DOI:10.3389/fneur.2014.00261.
Wang Y, Goodfellow M, Taylor PN, Baier G. (2014) Dynamic mechanisms of neocortical focal seizure onset, PLoS Comput Biol, volume 10, no. 8, DOI:10.1371/journal.pcbi.1003787.
Goodfellow M, Glendinning P. (2013) Mechanisms of intermittent state transitions in a coupled heterogeneous oscillator model of epilepsy, J Math Neurosci, volume 3, no. 1, DOI:10.1186/2190-8567-3-17.
Al-Nuaimi Y, Goodfellow M, Paus R, Baier G. (2012) A prototypic mathematical model of the human hair cycle, J Theor Biol, volume 310, pages 143-159, DOI:10.1016/j.jtbi.2012.05.027.
Goodfellow M, Schindler K, Baier G. (2011) Intermittent spike-wave dynamics in a heterogeneous, spatially extended neural mass model, Neuroimage, volume 55, no. 3, pages 920-932, DOI:10.1016/j.neuroimage.2010.12.074.