Dr Junning Chen
Senior Lecturer - Bioengineering (E&R)
Telephone: 01392 722162
Extension: (Streatham) 2162
Dr. Junning Chen is a senior lecturer in Biomechanics, with primary research interests in pathological changes of tissue structures and functionality, including osteoarthritis and bone resorption. The research programme combines multiscale bio-tissue imaging techniques (e.g. microCT, Confocal Laser Scanning Microscopy, Scanning Electron Microscopy, Synchrotron x-ray Scattering, etc.) and numerical techniques (e.g. reserve engineering modelling, finite element analysis, dynamic modelling, etc.), to explore the effects of mechanical factors on microscopic tissue response and nanoscopic cellular and extracellular matrix responses under healthy, pathological and clinically treated conditions. The knowledge gained from this combined ex-vivo and in-silico approaches will be further applied in developing new biomaterial/structure through morphological optimisation, advanced prototyping (CAD-CAM and 3D printing) and in-vivo evaluation. Currently, the ongoing projects include
1) Residual Ridge Resorption of Mandible induced by Denture Wearing
2) Ultrastructurral and Mechanical Changes in Cartilage Ageing and Degeneration
3) Interface Structure and Biomechanics at the Calvarial Sutures in Skull
After graduating with 1st class honours degree and discipline merit in Mechanical Engineering from the University of Sydney in Australia, Junning worked in ResMed Pty Ltd, the world-leading company on non-invasive treatment for sleep apnoea, for a year before starting his PhD in Biomedical Engineering.
His PhD study was supported by the Commonwealth Government of Australia through Australian Postgraduate Award (APA) and the University of Sydney through University Postgraduate Award (UPA) for four years. At the last year of his study, he was awarded by the Australian Research Council (ARC) for Academic Merit. Through his PhD, 11 full-length papers were published on top international journals, including Journal of Biomechanics, Biomechanics and Modeling in Mechanobiology, Royal Society of Interface, Journal of the Mechanical Behavior of Biomedical Materials, etc.
Fellowships and Previous Grants
Upon the completion of PhD in 2015, Junning received his first PI fellowship founded by the German Research Council (DFG) through Berlin-Brandenburg School for Regenerative Therapies (Charité – Universitätsmedizin Berlin), to investigate the mechanical loading effects on the bone modelling and cell (osteocyte) network architecture variation by combining confocal laser scanning microscopy and finite element modelling.
A year later, Junning received his second PI fellowship from Alexander von Humboldt Foundation to investigate the osteocyte architecture and mineralized extracellular matrix around a fluid-rich soft tissue joint at the calvaria suture, a typical soft-hard tissue interface. This work was hosted by the Department of Biomaterials in Max Planck Institute of Colloids and Interfaces (MPIKG). In the meantime, Junning was also awarded as a CoI in a Fostering Joint International Research Grant from Japan Society for the Promotion of Science (JSPS), with his collaborators from Tohoku University there.
Soon after Junning started his lectureship in UoE in September 2017, he was awarded with Outward Mobility Academic Fellowship from the University, to visit one of his current research collaboration group in University of British Columbia (UBC) for experiment work and future grant application.
EPSRC New Investigator Award £249k
EPSRC DTP £77k
EPSRC Core Capital Fund £73k
ImagingBioPro Proof of Concept Awards £23k
OATech+ Network Biomechanics Pump-Priming Fund £10k
Both domestic and international students are welcome to apply for their PhD with Dr. Junning Chen, and available funding opportunities can be found through the University Funding Database or through their individual national funding agencies.
More Information about Junning