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Mr Ryan Stuart Edginton

PhD Candidate

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Ryan completed his MPhys undergraduate masters degree at the University of Exeter in 2013 following a two year research project investigating the mechanical impact of apoptosis on the dipole potential of the red blood cell membrane.

Now working on his PhD under Dr. Francesca Palombo  as a member of Prof. Nick Stone's Biomedical Spectroscopy Labs, part of the Biomedical Physics Group at Exeter, he studies the role of hydration within the main structural proteins of the extracellular matrix, collagen and elastin. Using a dual-frequency approach applying Brillouin light scattering spectroscopy and quasi-static stress-strain testing, he probes the viscoelastic properties of the hierarchical fibre mechanics. He extracts complementary structural information spectroscopically, through the use of Raman microscopy and micro-FTIR spectroscopic imaging, with potential to apply two-photon fluorescence and single harmonic generation microscopy, developing an understanding of the biomechanics and structure-function relationships that govern the physics and chemistry of mammalian tissue.

Ryan performs the role of Outreach Officer for the Biomedical Physics Group and is an academic Instructor to the Gold medal winning, University of Exeter International Genetically Engineered Machines (iGEM) team.

 

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Education

  • 2014 - Pres.     Doctor of Philosophy in Physics (DPhil) - University of Exeter
  • 2009 - 2013     Master of Physics (MPhys Hons.) - University of Exeter

 

Publications

  • Palombo F, Edginton RS et al, Biomechanics of fibrous proteins of the extracellular matrix studied by Brillouin scattering. J. R. Soc. Interface 11: 20140739 (2014)
  • Edginton, R. S. et al, Preparation of Extracellular Matrix Protein Fibres for Brillouin Spectroscopy, J. Vis. Exp. (115) e54648 doi: 10.3791/54648 (2016)

 

Conferences & Invited Talks

  • “A multiscale analysis of the mechanical properties of the fibrous proteins of the extracellular matrix using Brillouin light scattering spectroscopy“ - (Oral Presentation & Poster) SciX2016 (Minneapolis - 21/09/2016)
  • "More than just a laser pointer: Light Scattering and the Physics of Biology" - (Invited Talk) Pint of Science 2016 (Exeter - 25/05/2016)
  • "Brillouin Light Scattering Spectroscopy and Elasticity in Hydrated Connective Tissue" - (Oral Presentation) 13th Martin & Willis Student Meeting - Infrared & Raman Discussion Group (Exeter - 26/08/2015)
  • "The Effect of Hydration on the Macroscopic Elastic Modulus of Type I Collagen and Elastin Fibres" - (Oral Presentation) 21st Congress of the European Society of Biomechanics (Prague - 06/07/2015)
  • "The Biophysics of the Extracellular Matrix" - (Invited Talk) University of Perugia Department of Physics (Perugia - 12/03/2015) 

 

Awards & Competitions

  • Winner: Best Final Year Poster  - "Brillouin Light Scattering Spectroscopy: Sensing the Elasticity of Connective Tissue"  (Exe-BioCon 2016, Exeter - 14/06/2016)
  • SET for Britain 2016 Finalist -  "Brillouin Light Scattering Spectroscopy: Sensing the Elasticity of Connective Tissue"  (Houses of Parliament, Westminster - 07/03/2016)

 

Funding

  • £300 - "IPEM Student and Trainee Travel Grant" - to support attendance to SciX2016, Minneapolis, USA (AUG 2016)
  • £175 - "C R Barber Trust Fund" - for accommodation at SciX2016, Minneapolis, USA (JULY 2016)
  • £300 - "IOP Student Conference Fund" - for accommodation at SciX2016, Minneapolis, USA (JULY 2016)
  • £1000 - "Santander Postgraduate Research Award" - for one month residential and facilities usage at the Department of Physics, University of Perugia, Italy (JAN 2015)

 

Contributions to the Community

  • iGEM 2016 Giant Jamboree Judge - Hynes Convention Centre, Boston (27/10/2016 - 31/10/2016)
  • iGEM 2015 Giant Jamboree Judge - Hynes Convention Centre, Boston (25/09/2015 - 28/09/2015)

 

Outreach & Engagement

  • Exeter Progression in Physics: Biomedical Physics - Exeter (06/04/2016)
  • University of Exeter Community Day - Exeter (20/03/2016)
  • Britain Needs Scientists: Speed Dating - Exeter (16/03/2016)
  • Royal Society of Chemistry ChemNet: "Meet the BioSpec Team @ Exeter"  - Exeter (14/12/2015)

 

Memberships

  • Associate Member of the Institute of Physics (IOP)
  • Student Member of the European Society of Biomechanics
  • Associate Member of the Institute of Physics and Engineering in Medicine (IPEM)
  • Student Member of the Society of Applied Spectroscopy
  • Student Member of the International Society for Clinical Spectroscopy (CLIRSPEC)
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