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Professor Nick Stone

• Profile
• Publications

Professor Nick Stone

Professor of Biomedical Imaging and Biosensing

Extension: 6531

Telephone: 01392 726531

Prof Nick Stone is a Professor of Biomedical Imaging and Biosensing at the University of Exeter. He holds a NIHR Career Scientist Research Fellowship and maintains an honorary position of Consultant Clinical Scientist within Gloucestershire Hospitals NHS Foundation Trust. Until recently Nick led the Biophotonics Research Unit based at Gloucester. The Unit has been involved in pioneering the field of novel optical diagnostics within the clinical environment. It works closely at the clinical/academic/commercial interface to pull-through novel technologies to be used where they have most clinical need.

Nick graduated with a BSc(Hons) from Bath University in Applied Physics with Industrial Training in 1992. Since then he has undertaken numerous studies which include: an MSc with Distinction from Heriot-Watt and St Andrews Universities in Laser Engineering with Applications; an MSc with Distinction in Applied Radiation Physics with Medical Physics at Birmingham University; a PhD in the application of Raman spectroscopy for cancer diagnostics at Cranfield University and an MBA (Health Executive) at Keele University. Nick has received numerous awards for his research both personally and within his research group. He recently won the Chief Scientific Officer’s National R&D Award for 2009. He has published over 100 papers and book chapters and received over £5M grant funding.

Publications Book Chapters 2004 Barr, H, Stone, N, Preventing Reflux-Associated Cancer: Focus on Asprin and PPIs. In MIMS Advances: Upper GI Disorders, 5-7. 2007 Hugh Barr, Joanne Hutchings, Catherine Kendall, Florian Bazant-Hegemark, Nicholas Stone. Endoscopic Approaches to the treatment of early malignancy and their relationship to clinical outcome. In: UK Key Advances in Clinical practice Series. The effective management of Upper Gastrointestinal malignancies, 2nd edition. Eds. Wendy L. Allen, Vicky Coyle and Patrick G. Johnston. 2008 Stone, N., Kendall, C., Barr, H, ‘Applications of vibrational spectroscopy in medical diagnosis: Raman spectroscopy as a potential tool for early diagnosis of malignancies in esophageal and bladder tissues.’ in Diem, M, Chambers, J, Griffiths, P, 'Vibrational Spectroscopy for Medical Diagnosis' , Wiley. 2008 Stone, N, Kendall, CA, ‘Raman spectroscopy for early cancer detection, diagnosis and elucidation of disease specific biochemical changes.’ In: Emerging Biomedical and Pharmaceutical Applications of Raman Spectroscopy Eds. Pavel Matousek & Michael Morris. Pub. Springer Series Biological and Medical Physics. 2009 Barr H, Shetty, G, Stone N, Kendall, C. ‘Barrett's oesophagus-how should I treat it.’ pp 15-27, In Recent Advances in Gastroenterology 11 ed Probert C Royal Society of Medicine Press Ltd London 2010 Sockalingum, G, Byrne, H, Stone, N, ‘ Raman microscopy: Compliment or competitor?’, pp 105-142, In Biomedical Applications of Sychrotoron Infrared Mircospectroscopy., Ed David Moss, RSC Publishing (Cambridge). Peer Reviewed Papers 1993 Marshall, P., Stone, N.,‘Fibre-matrix interface transverse tensile debonding’, Journal of Material Science Letters, 12 (4), 218-219. 1998 Barr, H., Dix, A., Stone, N., ‘Optical Spectroscopy for the Early Diagnosis of Gastrointestinal Maliganancy.’, Lasers in Medical Science, 13:3-13. 1999 Fulljames, C., Stone, N., Bennett, D., Barr, H., ‘Beyond White Light Endoscopy – The Prospect for Endoscopic Optical Biopsy.’, Italian Journal of Gastroenterology and Hepatology, 31:695-704. 1999 Tan, W.C., Fulljames, C., Stone, N., Dix, A.J., Shepherd, N., Roberts, D.J.H., Brown, S.B., Krasner, N., Barr, H, ‘Photodynamic therapy using 5-aminolaevulinic acid for oesophageal adenocarcinoma associated with Barrett’s metaplasia.’, J. Photochem. Photobiol. B: Biol, 53:75-80. 2000 Stone, N., Stavroulaki, P., Kendall, C., Birchall, M., Barr, H., ‘Raman Spectroscopy for Early Detection of Laryngeal Malignancy – Preliminary Results.’, The Laryngoscope, 110, 1756-1763. 2001 Barr, H., Dix, A.J., Kendall, C., Stone, N., ‘The Potential Role for Photodynamic Therapy in the Management of Upper Gastrointestinal Disease.’, Alimentary Pharmacology and Therapeutics, 15, 311-321. 2002 Stone, N., Kendall, C., Shepherd, N., Crow, P., Barr, H., ‘Near-Infrared Raman Spectroscopy for the Classification of Epithelial Pre-Cancers and Cancers.’, Journal of Raman Spectroscopy, 33, 7, 564-573. 2002 Crow, P., Kendall, C., Wright, M., Persad, R., Ritchie, A., Stone, N., ‘The use of Raman spectroscopy to distinguish between normal tissue, carcinoma in situ and TCC within the bladder.’, British Journal of Urology, 90(1), 71. 2002 Barr H., Kendall, C., Reyes-Goddard, J., Stone, N., ‘Clinical Aspects of Photodynamic Therapy.’, Science Progress, 85(2), 131-150. 2003 Barr, H, Kendall, C, Stone, N, ‘Photodynamic Therapy for Esophageal Cancer: A Useful and Realistic Option.’ Technology in Cancer Research and Treatment, 2(1), 65-75. 2003 Kendall, C., Stone, N., Shepherd, N., Geboes, K., Warren, B., Bennett, R., Barr, H., ‘Raman Spectroscopy a potential tool for the objective identification and classification of neoplasia in Barrett’s oesophagus.’, Journal of Pathology, 200, 5, 602-609. 2003 Crow, P, Stone, N, Kendall, CA, Uff, JS, Farmer, JAM, Barr, H, Wright, MJP, ‘The use of Raman spectroscopy to identify and grade prostatatic adenocarcinoma in vitro.’, British Journal of Cancer, 89, 1, 106-109. 2003 Smith, J, Stone, N, Kendall, C, Christie-Brown, J, Shepherd, N, Sammon, A, Barr, H, ‘Raman spectroscopy: a novel optical technique for the diagnosis and management of carcinoma of the oesophagus and breast, and lymph node metastases.’, British Journal of Surgery, 90 (5), 637. 2003 Stone, N, ‘Standardising dosimetry in esophageal PDT: an argument for use of centring devices and removal of misleading units.’, Technology in Cancer Research and Treatment, 2, 4, 333-338. 2003 Smith, J, Kendall, C, Sammon, A, Christie-Brown, J, Stone, N, ‘Raman Spectral Mapping in the Assessment of Axillary Lymph Nodes in Breast Cancer.’, Technology in Cancer Research and Treatment, 2, 4. 2003 Crow, P, Stone, N, Kendall, C, Persad, RA, Wright, MJP, ‘Optical diagnostics in Urology: Current applications and future prospects.’, British Journal of Urology International, 92, 4, 400-407. 2004 Stone, N, Kendall, C, Smith, J, Crow, P, Barr, H, ‘Raman spectroscopy for identification of epithelial cancers.’ Faraday Discussions: Applications of Spectroscopy to Biomedical Problems, 126, 141-157. 2004 Sule-Suso, J, Forster, A, Zholobenko, V, Stone, N, El Haj, A, ‘Effects of CaCl2 and MgCl2 on Fourier transform infrared (FT-IR) spectra of lung cancer cells.’, Applied Spectroscopy, 58, 1, 61-67. 2004 Crow, P, Uff, JS, Farmer, JA, Wright, MP, Stone, N, ‘The use of Raman spectroscopy to identify and characterize transitional cell carcinoma in vitro.’, BJU International, 93, 1232-1236. 2004 Barr, H, Kendall, C, Stone, N, ‘The Light solution for Barrett’s Oesophagus. Photodiagnosis and Photodynamic therapy for Columnar-lined Oesophagus.’, Photodiagnosis and Photodynamic Therapy, 1, 75-84. 2005 Barr, H, Stone, N, Rembacken, B, ‘Endoscopic Therapy for Barrett’s Oesophagus.’, GUT, 54, 6, 875-884. 2005 Crow P, Molckovsky A, Stone N, Uff J, Wilson B, Wongkeesong L-M, ‘Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer.’, Urology, 65, 6, 1126-30. 2005 Hart Prieto, MC, Matousek, P, Towrie, M, Parker, AW, Wright, M, Ritchie, AW, Stone, N, ‘The use of picosecond Kerrgated Raman spectroscopy to suppress signals from both surface and deep layers in bladder and prostate tissue.’ Journal of Biomedical Optics, 10, 4. 2005 Crow P, Barrass B, Kendall C, Hart-Prieto M, Wright M, Persad R, Stone N, ‘The use of Raman spectroscopy to differentiate between different prostatic adenocarcinoma cell lines.’ British Journal of Cancer, 92, 12, 2166-2170. 2005 Reyes-Goddard J, Barr H, Stone N, ‘Photodiagnosis using Raman and surface enhanced Raman scattering of bodily fluids.’ Photodiagnosis and Photodynamic Therapy, 2, 223-233. 2006 Shetty, G, Kendall, C, Shepherd, N, Stone, N, Barr, H ‘Raman spectroscopy:Elucidation of biochemical changes in carcinogenesis of oesophagus.’ British Journal of Cancer, 94, 1460-1464. 2006 Barr, H, Kendall, C, Bazant-Hegemark, F, Stone, N ‘How I do it:Endoscopic Photodynamic Therapy for Oesophageal Disease.’ Photodiagnosis and Photodynamic therapy, 3, 1, 102-105. 2006 Barr, H, Kendall, C, Bazant-Hegemark, F, Moayyedi, P, Shetty, G, Stone, N, ‘Endoscopic screening and surveillance for Barrett’s Esophagus-clinical implications.’ MedGenMed Gastroenterology, 8, 2, 88. 2006 Sowa, MG, Smith, MSD, Kendall, C, Bock, ER, Ko, AC-T, Choo-Smith, L-P, Stone, N, ‘Compositional Modeling of Multicomponent Systems Using Semi-Parametric Regression of Raman Spectra.’ Applied Spectroscopy, 60, 8, 877-883. 2006 Das, K, Stone, N, Kendall, C, Fowler, C, Christie-Brown, J, ‘Raman spectroscopy of parathyroid tissue pathology.’ Lasers Med Sci, 21: 192–197. 2007 Baker, R, Matousek, P, Ronayne, KL, Parker, AW, Rogers, K, Stone, N, ‘Depth profiling of calcifications in breast tissue using picosecond Kerr-gated Raman spectroscopy.’, Analyst, 132, 48 - 53. 2007 Das, K., Stone, N, Kendall, C., Fowler, C., Christie-Brown, J., ‘Role of Fourier transform infrared spectroscopy (FTIR) in the diagnosis of parathyroid pathology.’ Photodiagnosis and Photodynamic Therapy, 4, 124—129. 2007 Stone, N, Hart Prieto, MC, Crow, P, Uff, J, Ritchie, AW, ‘The use of Raman spectroscopy to provide an estimation of the gross biochemistry associated with urological pathologies.’ Anal Bioanal Chem, 387, 5, 1657-1668, DOI 10.1007/s00216-006-0937-9. 2007 Taylor, JC, Kendall, CA, Stone, N, Cook, TA., ‘Optical adjuncts for enhanced colonoscopic diagnosis.’ British Journal of Surgery, 94, 1, 6-16. 2007 Filik, J, Stone, N, ‘Drop coating deposition Raman spectroscopy of protein mixtures.’, Analyst, 132, 544 - 550. 2007 Stone, N, Baker, R, Rogers, K, Parker, AW, Matousek, P, ‘Future possibilities in the diagnosis of breast cancer by subsurface probing of calcifications with spatially offset Raman spectroscopy (SORS).’, Analyst, 132, 899 – 905. 2007 Matousek, P, Stone, N, ‘Prospects for the Diagnosis of Breast Cancer by Non-Invasive Probing of Calcifications using Transmission Raman Spectroscopy.’ Journal of Biomedical Optics, 12, 2, 024008. 2007 Bazant-Hegemark, F, Stone, N, McKenzie, G, Holmes, J, ‘Optical coherence tomography aids cancer detection.’, Biophotonics International, 14 (11), 46-47. 2008 Isabelle, M, Stone, N, Barr, H, Vipond, M, Shepherd, N, Rogers, K, ‘Lymph Node Pathology Using Optical Spectroscopy in Cancer Diagnostics.’, International Journal of Spectroscopy, 22, 2-3, 97-104. 2008 Reyes-Goddard, J.M., Barr, H., Stone, N., ‘Surface enhanced Raman scattering of herpes simplex virus in tear film.’, Photodiagnosis and Photodynamic Therapy, 5, 1, 42-49. 2008 Barr, H., Stone, N., Ding, D.C.D., Kendall, C. ‘Current practice in management of high-grade dysplasia in Barrett's oesophagus: The real problem.’ Photodiagnosis and Photodynamic Therapy, 5, 1, 38-41. 2008 Filik, J, Stone, N, ‘Analysis of human tear fluid by Raman spectroscopy.’, Analytica Chimica Acta, 616, 2, 177-184. 2008 Bazant-Hegemark F, Stone N, ‘Near real-time classification of Optical Coherence Tomography data using Principal Components fed Linear Discriminant Analysis.’ Journal of Biomedical Optics, 13, 3, 034002. 2008 Stone, N, Matousek, P, ‘Advanced Transmission Raman Spectroscopy – a promising tool for breast disease diagnosis.’ Cancer Research, 68: 4424-4430. 2008 Kaustuv Das, Nicholas Stone, Catherine Kendall, Martin Isabelle, Clare Fowler, J Christie-Brown. ‘FTIR of Touch Imprint Cytology: A novel tissue diagnostic technique.’ Journal of Photochemistry and Photobiology B: Biology, 92, 160-164. 2008 Bird, B., Miljkovic, M., Romeo, M., Diem, M., Smith, J., Stone, N., George, M., ‘Infrared Micro-Spectral Imaging: Automatic Distinction of Cell Types in Axillary Lymph Node Histology.’, BMC Clinical Pathology 8, 8. 2008 Keller MD, Kanter EM, Lieber CA, Majumder SK, Hutchings J, Ellis DL, Beaven RB, Stone N, Mahadevan-Jansen A, ‘Detecting Temporal and Spatial Effects of Epithelial Cancers with Raman Spectroscopy’ Disease Markers, 25, 6, 323-337. 2008 Bazant-Hegemark F, Stone N, ‘Optical coherence tomography: A potential tool for unsupervised prediction of treatment response for Port-Wine Stains.’, PDPDT, 5, 3, 191-197. 2008 Bazant-Hegemark F, Edey K, Swingler GR, Read MD, Stone N: ‘Review: Optical micrometer resolution scanning for non-invasive grading of pre-cancer in the human uterine cervix.’ Technology in Cancer Research and Treatment, 7, 6, 483-496. 2009 Bazant-Hegemark F, Stone N, ‘Towards automated classification of clinical optical coherence tomography data of dense tissues.’, Laser Medical Science, DOI 10.1007/s10103-008-0615-6. 2009 Filik, J. and Stone, N., ‘Investigation into the Protein Composition of Human Tear Fluid using Centrifugal Filters and Drop Coating Deposition Raman Spectroscopy.’, Journal of Raman Spectroscopy, 40, 2, 218-224. 2009 Hutchings, J., Kendall, C., Smith, B., Shepherd, N., Barr, H., Stone, N., ‘The potential for histological screening using a combination of rapid Raman mapping and principal component analysis.’ Journal of Biophotonics, 2, 91-103. 2009 Babrah, J, McCarthy, KP, Lush, R, Rye, AD, Bessant, C, Stone, N ‘Characterisation of T-cell Lymphoma, B-cell Lymphoid and Myeloid Leukaemia Cell Lines by Fourier Transform Infrared Spectroscopy’ , Analyst, DOI 1039/b807967f. 2009 Matousek, P., Stone, N., ‘Emerging Concepts in Deep Raman Spectroscopy of Biological Tissue.’, Analyst, DOI 10.1039/b821100k. 2009 Grimbergen, MGM, van Swol, CFP, van Moorselaar, RJA, Mahadevan-Jansen, A, Uff, J, Stone, N, ‘Effect of 5-ALA on NIR Raman Spectroscopy of tissue.’ Journal of Photochemistry and Photobiology B: Biology, 95, 170–176. 2009 Kendall, C, Isabelle, M, Hutchings, J, Babrah, J, Orr, L, Baker, R, Bazant-Hegemark, F, Stone, N, ‘Vibrational spectroscopy: a clinical tool for cancer diagnostics.’ Analyst, 134, 1029-1045. 2009 Upile, T, Jerjes, W, Sterenborg, HJCM, et al. ‘Head & neck optical diagnostics: vision of the future of surgery.’, Head & Neck Oncology, 1:25 doi:10.1186/1758-3284-1-25 2009 J C C Day, R Bennett, B Smith, C Kendall, J Hutchings, G M Meaden, C Born, S Yu and N Stone, ‘A miniature confocal Raman probe for endoscopic use.’ Phys. Med. Biol. 54 7077-7087. 2010 MCM Grimbergen, CFP van Swol, C. Kendall, RM Verdaasdonk, N Stone, JLHR Bosch, ‘Signal to noise contribution of principal component loads in reconstructed NIR Raman tissue spectra.’, Applied Spectroscopy, 64(1). 2010 Isabelle, M, Rogers, K, Stone, N, ‘Correlation mapping: rapid method for identification of histological features and pathological classification in mid infrared spectroscopic images of lymph nodes.’ JBO, 15(2), 026030. 2010 Stone, N, Faulds, K, Graham, D, Matousek, P, ‘Prospects of Deep Raman Spectroscopy for Noninvasive Detection of Conjugated Surface Enhanced Resonance Raman Scattering Nanoparticles Buried within 25 mm of Mammalian Tissue.’ Analytical Chemistry, 82 3969. 2010 Sattlecker, M, Bessant, C, Smith, J, Stone, N, ‘Investigation of support vector machines and Raman spectroscopy for lymph node diagnostics.’ Analyst, 135 (5), 895-901. 2010 Hughes, OR, Stone, N, Kraft, M, Arens, C, Birchall, MA, ’Optical and molecular techniques to identify tumor margins within the larynx.’ Head and Neck, 32(11), 1544-1553. 2010 Pijanka, JK, Stone, N, Cinque, C, Yang, Y, Kohler, A, Wehbe, K, Frogley, M, Parkes, G, Parkes, J, Dumas, P, Sandt, C, van Pittius, DG, Douce, G, Sockalingum, GD, Sule-Suso, J, ’FTIR microspectroscopy of stained cells and tissues. Application in cancer diagnosis.’ Spectroscopy, 24, 73-78. 2010 Hugh Barr; Catherine Kendall; Joanne Hutchings; Florian Bazant-Hegemark; Shepherd N; Stone N, ‘Rapid Endoscopic Identification and Destruction of Degenerating Barrett’s Mucosal Neoplasia.’ , King James IV Lecture, The Surgeon. 2010 Baker, R, Rogers, KD, Shepherd, N, Stone, N ‘New relationships between breast microcalcifications and cancer.’, BJC, 103, 1034-1039. 2010 Sattlecker, M, Stone, N, Smith, J, Bessant, C, ‘Assessment of robustness and transferability of classification models built for cancer diagnostics using Raman spectroscopy.’, JRS, DOI 10.1002/jrs.2798. 2010 Horsnell, J, Stonelake, P, Christie-Brown, J, Shetty, G, Hutchings, J, Kendall, C, Stone, N, ‘Raman Spectroscopy – A New Method for the Intra-Operative Assessment of Axillary Lymph Nodes.’ Analyst, 135, 12, 3042-3047. 2010 Kerssens, MM, Matousek, P, Rogers, KD, Stone, N, ‘Towards a safe non-invasive method for evaluating the carbonate substitution levels of hydroxyapatite (HAP) in micro-calcifications found in breast tissue.’ Analyst, 135 (12), 3156 - 3161. 2010 Kendall, C, Day, J, Smith, B, Hutchings, J, Shepherd, N, Barr, H, Stone, N, ‘Confocal Raman probe for early endoscopic cancer diagnostics.’ Analyst, 135, 12, 3038-3041. 2010 Hutchings, J, Kendall, C, Shepherd, N, Ludeman, L, Barr, H, Stone, N, ‘Evaluation of linear discriminant analysis for automated Raman histological mapping of oesophageal high grade dysplasia.’ JBO, 15, 066015. 2011 Humphreys, ML, Orme, R, Moore, P, Charaklias, N, Sahgal, N, Planas, NP, Magan, N, Stone, N, Kendall, CA, ‘Electronic nose analysis of bronchoalveolar lavage fluid.’ European Journal of Clinical Investigation DOI: 10.1111/j.1365-2362.2010.02376, 41, 1, 52-58. 2011 Kendall, C, Hutchings, J, Barr, H, Shepherd, N, Stone, N, ‘Exploiting the diagnostic potential of biomolecular fingerprinting with vibrational spectroscopy.’ Faraday Discussions, 149 (1), 279 - 290. 2011 Stone, N, Kerssens, M, Lloyd, GR, Faulds, K, Graham, D, Matousek, P, ‘Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging – the next dimension.’, Chemical Science, 2 (4), 776-780. 2011 Upile, T, Jerjes, WK, Sterenborg, HJ, et al, ‘At the frontiers of surgery: review.’, Head and Neck Oncology, 3, 7. 2011 Horsnell, J.D., Smith, J.A., Sattlecker, M., Sammon, A., Christie-Brown, J, Kendall, C, Stone, N, ‘Raman spectroscopy - A potential new method for the intra-operative assessment of axillary lymph nodes.’, Surgeon (in press). 2011 Sattlecker, M, Baker, R, Stone, N, Bessant, C, ‘Support Vector Machine Ensembles for Breast Cancer Type Prediction from Mid-FTIR Micro-calcification Spectra.’, Chemometrics and Intelligent Laboratory Systems (in press). 2011 Almond, LM, Hutchings, J, Shepherd, N, Barr, H, Stone, N, Kendall, C, ‘Raman spectroscopy: a potential tool for early objective diagnosis of neoplasia in the oesophagus.’, Journal of Biophotonics, DOI 10.1002/jbio.201100041. 2011 Jerjes, WK, Upile, T, Wong, BJ, et al. ‘ The future of medical diagnsotics: review paper.’, Head and Neck Oncology, 3, 38. DOI:10.1186/1758-3284-3-38. 2012 Lloyd, GR, et al. ‘Rapid Raman histological imaging of colon pathology coupled to Self Organising Maps.’, Submitted Vibrational Spectroscopy. 2012 Almond, LM et al. ‘Assessment of a custom-built Raman spectroscopic probe for diagnosis of early oesophageal neoplasia.’ JBO. 2012 Hai-nan Xie, Ross Stevenson, Nicholas Stone, Aaron Hernandez-Santana, Karen Faulds, Duncan Graham, ‘Tracking Bisphosphonates through a 20 mm Thick Porcine Tissue by Using Surface-Enhanced Spatially Offset Raman Spectroscopy.’ Angew. Chem. Int. Ed., 51. 2012 Day, J, Stone, N, ‘A subcutaneous Raman needle probe.’, Applied Spectroscopy (Accepted). Published Proceedings and Abstracts 1996 Stone, N., Barr, H., Ahmad, R., ‘Optical Measurements on Human Synovial Fluid and its Relevance to Pathology.’, Proceedings of Conference on Optical Imaging Techniques for Biomonitoring, SPIE 2927, Vienna. 2000 Stone, N., Stavroulaki, P., Fulljames, C.A., Birchall, M., ‘Raman spectroscopy: A Diagnostic Tool for Detection of Early Maliganant Changes in the Larynx.’, SPIE 3918, p120-128, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, San Jose, California. 2000 Bakker Schut, T.C., Stone, N., Fulljames, C., Barr, H., Bruining, H.A., Puppels, G.J., ‘Progress in the detection of neoplastic progress and cancer by Raman spectroscopy.’, SPIE 3918, p106-113, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, San Jose, California. 2000 Kendall, C., Bakker Schut, T., Stone, N., Stavroulaki, P., Puppels, G., Barr, H., ‘Raman spectroscopy for the diagnosis of dysplasia in columnar and squamous epithelium..’, SPIE 4161, Ebios, Amsterdam. 2002 Stone, N., Kendall, C., Chandratreya, N., Shepherd, N., Barr, H., ‘Near-infrared Raman spectroscopy for detection and classification of gastrointestinal disease..’, SPIE 4614-21, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques II, San Jose, California. 2002 Kendall, C., Barr, H., Shepherd, N., Stone, N., ‘Optimum Procedure for Construction of Spectral Classification Algorithms for Medical Diagnosis.’, SPIE 4614-25, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques II, San Jose, California. 2003 Crow P, Stone N, Kendall C, Uff J, Ritchie A, Wright M, ‘Optical diagnostics in bladder cancer: The use of Raman spectroscopy to differentiate between bladder pathologies in vitro.’, Journal of Urology, 169 (4), 871, Suppl. S. 2003 Smith, J, Kendall, C, Christie-Brown, J, Sammon, A, Stone, N, ‘Raman spectroscopy in the assessment of breast cancer and axillary lymph node metastasis.’, SPIE 5141-43, Diagnostic Optical Spectroscopy in Biomedicine II, Munich. 2003 Reyes-Goddard, JM, Woodman, AC, Stone, N, Barr, H, Creighton, JA, Saito, Y, Batchelder, D, ‘Surface enhanced Raman scattering of the tear film.’, SPIE 5141-30, Diagnostic Optical Spectroscopy in Biomedicine II, Munich. 2003 Kendall, C, Shepherd, N, Barr, H, Stone, N, ‘Raman spectral mapping for the illumination of biochemical changes associated with malignancy in the oesophagus.’, SPIE 5141-32, Diagnostic Optical Spectroscopy in Biomedicine II, Munich. 2003 Kendall, C, McCloskey, K, Stone, N, Barr, H, Greenhalgh, D, ‘Multiphoton imaging in the detection of malignancy in the oesophagus.’, SPIE 5139-07, Confocal, Multiphoton, and Nonlinear Microscopic Imaging, Munich. 2003 Chandratreya, N, Stone, N, Kendall, C, Glass, RE, Barr, H, Shepherd, N, ‘Near Infra-red Raman spectroscopy: A new tool for detection and classification of colonic disease.’, British Journal of Surgery, 90 (S1), 65-68. 2003 Kendall, C, Crow, P, Smith, J, Orr, L, Chandratreya, N, Barr, H, Stone, N, ‘Raman spectroscopy for cancer diagnostics.’, Lasers in Medical Science, 18 (Suppl 1), O145, 48-49. 2003 Crow, P, Stone, Nm Kendall, C, Uff, J, Richie, A, Wright, M, ‘Optical diagnostics in bladder cancer: the use of Raman spectroscopy to differentiate between bladder pathologies in vitro.’, Lasers in Medical Science, 18 (Suppl 1), O142, 48. 2003 Smith, J, Kendall, C, Christie-Brown, J, Sammon, A, Stone, N, ‘Raman spectroscopy in the assessment of breast cancer and axilliary lymph node metastases.’, Lasers in Medical Science, 18 (Suppl 1), O143, 48. 2003 Crow, P, Stone, N, Kendall, C, Uff, J, Gilbert, H, Persad, R, Wright, M, ‘Optical diagnostics in prostate cancer: the use of Raman spectroscopy to differentiate between prosatatic pathologies in vitro.’, Lasers in Medical Science, 18 (Suppl 1), O146, 49. 2003 Parsons, RJ, Moseley, H, Stone, N, ‘The development of UK laser safety regimes.’, Lasers in Medical Science, 18 (Suppl 1), O194, 65. 2004 Hart Prieto, MC, Crow, P, Kendall, C, Uff, J, Wright, M, Ritchie, A, Stone, N, ‘Urological applications of Raman spectroscopy for improved malignant diagnostics.’, SPIE 5321A-17. 2004 Smith, J, Christie-Brown, J, Sammon, AM, Stone, N, ‘Axillary lymph node analysis using Raman spectroscopy.’, SPIE 5321A-18. 2004 Chandratreya, NV, Kendall, C, Glass, RE, Barr, H, Shepherd, N, Stone, N, ‘Spectroscopy Aided Oiptical Biopsy in the Colon.’, Colorectal Disease, 6 (S1), 27. 2005 Smith, J, Kendall, C, Sammon, AM, Christie-Brown, J, Mandalia, T, Stone, N, ‘Raman spectroscopy is sensitive and specific in the detection of lymph node metastases in breast cancer.’, SPIE 5862-02. 2006 R. Baker, J. Smith, N. Stone, K. D. Rogers, ‘Vibrational spectroscopic analysis of breast calcifications and surrounding tissue.’, SPIE 6093-32. 2006 N. Stone, M. C. Hart Prieto, C. A. Kendall, G. Shetty, H. Barr, ‘Raman spectroscopic biochemical mapping of tissues.’, SPIE 6093-29. 2006 K. Subramanian, N. Stone, C. A. Kendall, K. McCarthy, J. Brown, J. Bristol, C. Chan, ‘Infrared spectroscopy a novel tool to aid classification of DCIS.’, SPIE 6093-18. 2006 K. Subramanian, C. A. Kendall, K. McCarthy, J. Brown, J. Bristol, C. Chan, N. Stone, ‘Raman spectroscopic analysis of atypical proliferative lesions of the breast.’, SPIE 6088-12. 2006 M. C. Grimbergen, C. F. van Swol, R. J. A. van Moorselaar, N. Stone, ‘Feasibility of Raman spectroscopy in vitro after 5-ALA based fluorescence diagnosis in the bladder.’, SPIE 6078B-51. 2007 Archer JKJ, Sudworth CD, Mann D, Black RA, Stone N, ‘Improvements in Alzheimer's disease diagnosis using principal components analysis (PCA) in combination with Raman spectroscopy’; Proc. SPIE, 6628-37. 2007 Babrah, J, McCarthy, KP, Lush, R, Rye, AD, Bessant, C, Stone, N. ‘FT-Infrared Spectroscopic Studies of Lymphoma, Lymphoid and Myeloid Leukaemia Cell Lines’; Proc. SPIE, 6628-28. 2007 Aning, JJ, Isabelle, M, Uff, J, Ritchie, AWS, Gilbert, HW, Stone, N, ‘FTIR biochemical imaging of the prostate: An in-vitro proof of concept study.’, SPIE 6628-0F. 2007 Isabelle M, Aning JJ, Uff J, Ritchie AWS, Gilbert HW, Stone N, ‘FTIR biochemical imaging of the prostate: an in vitro proof of concept study’; Proc. SPIE, 6628-15. 2007 Baker, RN, Rogers, KD, Shepherd, N, Stone, N, ‘Analysis of Breast Tissue Calcifications using FTIR Spectroscopy’; Proc. SPIE, 6628-18. 2007 Bazant-Hegemark F, Stone N, Read MD, McCarthy K, Wang RK, ‘Optical coherence tomography (OCT) imaging and computer aided diagnosis of human cervical tissue specimens’, Proc. SPIE, 6627-65. 2008 Holmes, J., Hattersley, S., Stone, N., Bazant-Hegemark, F., Barr, H. ‘Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications.’ Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6847, art. no. 68470O. 2008 Hutchings, J., Kendall, C., Shepherd, N., Barr, H., Smith, B., Stone, N., ‘Rapid Raman microscopic imaging for potential histological screening.’, Biomedical Optical Spectroscopy – Proceedings of SPIE 6853, art. No. 685305. 2008 Filik, J., Stone, N., ‘Raman point mapping of tear ferning patterns.’, Biomedical Optical Spectroscopy – Proceedings of SPIE 6853, art. No. 685309. 2008 Stone, N., Baker, R., Hart Prieto, C., Matousek, P., ‘Novel Raman signal recovery from deeply buried tissue components.’, Biomedical Optical Spectroscopy – Proceedings of SPIE 6853, art. No. 68530N. 2009 Grimbergen, MCM, van Swol, CFP, van Diest, P, Dragad, ROP, Verdaasdonka, RM, Stone, N, Bosch, JHLR, ‘Bladder cancer diagnosis during cystoscopy using Raman spectroscopy.’ Biomedical Optical Spectroscopy – Proceedings of SPIE 7161B-203. 2010 Aneesh, A, Povazay, B, Hofer, B, Zhang, EZ, Kendall, C, Laufer, J, Popov, S, Glittenberg, C, Binder, S, Stone, N, Beard, PC, Drexler, W, ‘Optimizing penetration depth, contrast, and resolution in 3D dermatological OCT.’, SPIE-75540V. 2010 Linda E. Orr, Jonathan Christie-Brown, Joanne C. Hutchings, Catherine Kendall, Keith McCarthy, Simon Rose, Michael. Thomas, Nicholas Stone, ‘Raman spectroscopy as a tool for the identification and differentiation of neoplasias contained within lymph nodes of the head and neck.’ Proceedings of SPIE. 2010 Hutchings, J, Kendall, C, Shepherd, N, Barr, H, Day, J, Stone, N, ‘Ultra Low Resolution Raman mapping using a novel fibre optic probe.’, SPIE 75600N. 2011 Stone, N, Harnessing the power of light to provide real-time non-invasive molecular diagnostics., Science in Parliament.

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