Dr Jayakrupakar Nallala
Telephone: 01392 724149
Extension: (Streatham) 4149
Jayakrupakar’s research interests are to develop novel approaches for clinical diagnosis especially of molecular diseases such as cancers. For this, he is working on the forefront of cross disciplines by combining novel micro-spectroscopic imaging technologies with clinical practices of histopathology, immunohistochemistry, etc, to investigate bio-chemical changes in cells and tissues.
Currently a Research Fellow in the Cancer Research UK (CRUK) Grand Challenge 'Precision' project (https://www.dcisprecision.org/) to investigate why ductal carcinoma insitu (DCIS) propagates to breast cancer in few women and does not in others with the objective to avoid over treatment of DCIS (using surgery, radiation therapy and chemotherapy) which might not progress to cancer. Jayakrupakar is specifically investigating the physico-chemical features of breast tissues through the examination of micro-calcification microstructure. For this, a combination of novel spectroscopic techniques that include high-resolution coherent X-ray scatter for nano-structural information, infrared and Raman spectroscopy for direct measurement of micro-calcification and soft tissue molecular composition and novel data mining tools are being used. This data will be corroborated with the genetic and immunological information to identify biomarkers of DCIS that will progress to invasive cancer.
1. Worked as a Post-doctoral Research Fellow in the MINERVA project (http://minerva-project.eu/) funded by the European Union (FP7), in which a novel high-volume pathology screening approach for improved cancer diagnostics was demonstrated using new generation infrared spectroscopic imaging based on spectral histopathology/cytology. This was carried out with multi-national collaborations that brought together concepts from optics, photonics, data mining tools, virtual pathology and conventional clinical histopathology and immunohistochemistry.
2. Jayakrupakar obtained his PhD from the Université de Reims Champagne-Ardenne, France during which the potentials of vibrational spectroscopy as a cancer diagnostic tool were demonstrated via the concepts of spectral histopathology and infrared spectral barcoding in clinical colon tissue and tissue arrays.
3. His initial research activities at CCMB and ACTREC, India involved DNA sequencing and genotyping of single nucleotide and repeat length polymorphisms in specific genes and their association with breast, and head and neck cancers.
Education and Research Activities
2013- Ongoing Post-doctoral Research Fellow, University of Exeter, United Kingdom
2009-2012 PhD, Université de Reims Champagne-Ardenne, France
2006-2008 Research Associate, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Mumbai, India
2005-2006 MSc Dissertation, Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India
2004-2006 MSc Biotechnology, Bharathidasan University, Trichy, India
1999-2004 BSc Biotechnology (Distinction), Osmania University, Hyderabad, India
Funded Research Projects/Grants
1. Principal Investigator: Wellcome Trust ISSF Seed-Corn Fund Round 5, April 2018, £10,000
2. International travel grant from the Royal Society of Chemistry (RSC), September 2015, £800
3. Co-applicant of the Researcher-Led Initiative grant '‘Negative results: not junk, but an opportunity to learn'’ funded by the University of Exeter Researcher Development and Research Culture team, 2018, £1000
1. Invited speaker at the Rajiv Gandhi University of Knowledge Technologies-RGUKT Basar (IIIT), January 3rd 2017, Telangana, India
2. Invited speaker at SciX 2016, the annual meeting of the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), September 18-23, Minneapolis, USA
3. Invited speaker at the International Conference on Optical, Optoelectronic and Photonic Materials (ICOOPMA), 27th July-1st August 2014, Leeds, UK
4. Invited speaker at the GW4 Imaging Network Sandpit Event, 22nd January 2015, Exeter, UK
1. Diamond Synchrotron Infrared Beamline, United Kingdom (B22: Multimode Infrared Imaging and Microspectroscopy Beamline (MIRIAM)
2. Diamond Synchrotron X-ray micro-diffraction beamline (I18: Microfocus Spectroscopy)
Awards and Recognitions
1. Invited principal author to contribute an article to the special issue “Prominent Young Spectroscopists” of the journal Vibrational Spectroscopy, 2015
2. ‘Rambhau Kulkarni Young Scientist Award’ from the Indian Association for Cancer Research (IACR), February, 2008, Ahmedabad, India 3. Associate member of the Royal Society of Chemistry (RSC)
Other Professional Contributions:
Reviewer for international scientific journals: PLoS ONE, Journal of Raman Spectroscopy, Sensors, Biosensors