Photo of Dr Jayakrupakar Nallala

Dr Jayakrupakar Nallala

Research Fellow

Email:

Telephone: 01392 724149

Extension: (Streatham) 4149

Jayakrupakar’s research interests are to develop novel approaches for clinical diagnosis especially of molecular diseases such as cancers. For this, he is working on the forefront of cross disciplines by combining novel micro-spectroscopic imaging technologies with clinical practices of histopathology, immunohistochemistry, etc, to investigate bio-chemical changes in cells and tissues.

Present research:

Currently working as a Research Fellow in a Cancer Research UK (CRUK) Precision project to investigate why ductal carcinoma insitu (DCIS) propagates to breast cancer in few women and does not in others with the objective to avoid over treatment of DCIS (using surgery, radiation therapy and chemotherapy) which might not progress to cancer. Jayakrupakar is specifically investigating the physico-chemical features of breast tissues through the examination of micro-calcification microstructure. For this, a combination of novel spectroscopic techniques that include high-resolution coherent X-ray scatter for nano-structural information, infrared and Raman spectroscopy for direct measurement of micro-calcification and soft tissue molecular composition and novel data mining tools will be used. This data will be corroborated with the genetic and immunological information to identify biomarkers of DCIS that will progress to breast cancer. 

Past research:

1. Working as a Post-doctoral Research Fellow in the recently concluded MINERVA project (http://minerva-project.eu/) funded by the European Union (FP7), a novel high-volume pathology screening approach for improved cancer diagnostics was demonstrated using new generation infrared spectroscopic imaging based on spectral histopathology/cytology. This was carried out with multi-national collaborations that brought together concepts from optics, photonics, data mining tools, virtual pathology and conventional clinical histopathology and immunohistochemistry.  

2. Jayakrupakar obtained his PhD from the Université de Reims Champagne-Ardenne, France during which the potentials of vibrational spectroscopy as a cancer diagnostic tool were demonstrated via the concepts of spectral histopathology and infrared spectral barcoding in clinical colon tissue and tissue arrays. 

3. His initial research activities at CCMB and ACTRECIndia involved DNA sequencing and genotyping of single nucleotide and repeat length polymorphisms in specific genes and their association with breast, and head and neck cancers.

Jayakrupakar is an Associate member of the Royal Society of Chemistry (RSC), an Honorary fellow at the Biophotonics Research Unit, Gloucestershire Royal Hospitals NHS Foundation Trust, UK and was a recipient of the ‘Rambhau Kulkarni Young Scientist Award’ from the Indian Association for Cancer Research (IACR), 2008.

Education and Research Activities

2013- Ongoing       Post-doctoral Research Fellow, University of Exeter, United Kingdom
2009-2012              PhD, Université de Reims Champagne-Ardenne, France
2006-2008              Research Associate, Advanced Centre for Treatment Research and Education in Cancer (ACTREC),                                    Tata Memorial Centre, Mumbai, India
2005-2006              MSc Dissertation, Centre for Cellular and Molecular Biology (CCMB), Hyderabad, India
2004-2006              MSc Biotechnology, Bharathidasan University, Trichy, India
1999-2004              BSc Biotechnology (Distinction), Osmania University, Hyderabad, India

Invited talks

1. Invited speaker at the Rajiv Gandhi University of Knowledge Technologies-RGUKT Basar (IIIT), January 3rd 2017, Telangana, India
2. Invited speaker at SciX 2016, the annual meeting of the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), September 18-23, Minneapolis, USA
3. Invited speaker at the International Conference on Optical, Optoelectronic and Photonic Materials (ICOOPMA), 27th July - 1st August 2014, Leeds, UK
4. Invited speaker at the GW4 Imaging Network Sandpit Event, 22nd January 2015, Exeter, UK

Awards and Recognitions

1. Invited principal author to contribute an article to the special issue “Prominent Young Spectroscopists” of the journal Vibrational Spectroscopy, 2015
2. ‘Rambhau Kulkarni Young Scientist Award’ from the Indian Association for Cancer Research (IACR), February, 2008, Ahmedabad, India.  
3. International travel grant award (£800) from the Royal Society of Chemistry, September 2015. 

Other Professional Contributions:

Reviewer for international scientific journals: PLoS ONE, Journal of Raman Spectroscopy, Sensors

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