Monday 27 Mar 2017Dynamics Seminar: Oxidative stress in diabetes: Cause, consequence, or both?

Pranay Goel - Indian Institute of Science Education and Research (IISER) Pune

LSI Seminar Room A 16:00-17:00

It is well known that one of the major consequences of hyperglycemia in type 2 diabetes is increased oxidative stress (OS). In fact, OS forms the locus of all of the major complications that the disease leads to. Nonetheless, diabetes - not only progression but also its control during therapy - is measured exclusively in terms of blood glucose. We propose a novel idea: Is it possible to measure OS concurrently with glucose during antidiabetic therapy to ask if that can inform the personalization of treatment? I will describe a minimal mathematical model in this direction as a proof-of-concept of this proposal.

We further ask whether oxidative stress might also play a role in the development of diabetes? This is an intriguing possibility because OS is known to underlie the development of insulin resistance. I will describe a new mathematical model that may support this idea. This model is consistent with the so-called hypersecretion theory (Corkey, Banting Lecture 2011) which states that the essential casual event in diabetogenesis is oversecretion of insulin.

In summary, a continuing interest in our lab is to investigate the nuanced relationship that OS shares with glycemic stress not only in the development of diabetes but also its complications, and its control.

This includes joint work with Saroj Ghaskadbi, Department of Zoology, Savitribai Phule Pune University.

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