Engineering

Photo of Prof Tim Holsgrove

Prof Tim Holsgrove

Associate Professor of Biomedical Engineering

 T.Holsgrove@exeter.ac.uk

 (Streatham) 4682 or (Streatham) 6624 or (Streatham) 5943

 01392 724682 or 01392 726624 or 01392 725943

Overview

Tim Holsgrove is an Associate Professor of Biomedical Engineering, and is part of the Biomedical Engineering Research Group, an interdisciplinary collaboration between the Departments of Physics and Engineering.

Professor Holsgrove was awarded a MEng and PhD from the University of Bath, undertook post-doctoral research associate positions in the Centre for Orthopaedics Biomechanics and the Sports, Health & Exercise Science groups at the University of Bath, and in the Spine Pain Research Laboratory at the University of Pennsylvania, before joining the University of Exeter in November 2016 as a Lecturer. He is a Senior Fellow of the Academy of Higher Education.

Professor Holsgrove’s research focuses on developing and implementing novel methods to understand spinal injuries, degeneration, and treatments. He also works with various orthopaedic groups in the Princess Elizabeth Orthopaedic Centre at the Royal Devon and Exeter Hospital NHS Foundation Trust, and in 2017 he was awarded the Robin Ling Fellowship, which will develop research within the Hip Research Unit.

Current and recent projects include:

Co-I – 10055040 – JockeyCam Ltd Knowledge Transfer Partnership – (02/06/2023 – 01/06/2025) – £126,912.
Co-Chief Investigator – NIHR150537 - NIHR Efficacy and Mechanism Evaluation programme - HIPSTER – HIP Surgical Techniques to Enhance Rehabilitation (01/02/2023-31/01/2027) – £942,352.
Co-I – EP/V036602/1 – Image-Driven Subject-Specific Spine models (01/10/2021-30/09/2024) – £814,280.
PI – EP/S031669/1 – The development and implementation of a six-axis bioreactor for regenerative therapies of the intervertebral disc (01/01/2020-31/09/2023) – £222,239.
PI – Robin Ling Fellowship, Royal Devon & Exeter NHS Foundation Trust (01/10/2018-30/06/2023) – £93,326.

PI – EPSRC Impact Accelerator Account – Kinematic profiles of daily living to understand the spine (01/06/2023-30/09/2023) - £18,233.
Co-I – EPSRC DTP PhD studentship – Downsides of downhill: The adverse effects of head vibration associated with downhill mountain biking on visuomotor and cognitive function (01/10/2022 – 31/03/2026) – £80,678.
Co-I – Translational Research Exchange @ Exeter Wellcome Trust Seedcorn Fund – Developing, validating, and automating a novel ultrasound method for determining skeletal muscle quality (01/02/2022 – 31/10/2022) – £15,440.
PI – EPSRC DTP PhD studentship – A mechanobiochemical investigation into intervertebral disc health –A multidisciplinary approach using in-vivo, in-vitro, and in-silico methods  (20/09/2021 – 19/09/2025) – £77,444.
Co-I – Translational Research Exchange @ Exeter Wellcome Trust Public Engagement with Research – Biomedical Physics and Engineering research at Exeter – Data visualisation toolkit (01/05/2021 – 31/12/2022) – £1,000.
PI – UKRI Covid-19 Allocation related to EP/S031669/1 (22/04/2021) – £13,302.
Co-I – QUEX PhD studentship - Design, optimisation, and fabrication of patient-specific multi-phasic total disc replacements (01/10/2020 – 30/09/2024) ~£90,000.
Co-I – QUEX Initiator grant – The Effects of Ageing on the Nutrition and Mechanics of the Intervertebral Disc (01/04/2018-30/08/2018) – £10,000.

For more information about current and previous research, visit Prof Holsgrove's website.

If you are interested in a research collaboration, consultancy, or completing research with Prof Holsgrove please get in contact.

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Publications

Copyright Notice: Any articles made available for download are for personal use only. Any other use requires prior permission of the author and the copyright holder.

| 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2007 | 2006 | Patents |

2024

2023

  • Williams D, Ward M, Kelly E, Shillabeer D, Williams J, Javadi A, Holsgrove T, Meakin J, Holt C. (2023) BORS/BJR TRAVELLING FELLOWSHIP: IMAGE-DRIVEN SUBJECT-SPECIFIC SPINE MODELS: DEVELOPING A NOVEL TOOL TO MEASURE IN VIVO LOADING, Orthopaedic Proceedings, volume 105-B, no. SUPP_16, pages 50-50, DOI:10.1302/1358-992x.2023.16.050.
  • Rivera Tapia D. (2023) Development of in vitro methods to replicate the degeneration of the intervertebral disc.
  • Dixon W, Holsgrove T. (2023) Good Vibrations? An investigation examining the effects of speed, tyre pressure and wheel choice on whole-body vibration during road cycling, Science and Cycling Conference, Bilbao, Spain, 28th - 29th Jun 2023.
  • Kelly E, Javadi A, Holsgrove T, Ward M, Williams D, Shillabeer D, Holt C, Meakin J. (2023) Comparison of two machine-learning methods to predict intervertebral disc properties, International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Paris, France, 3rd - 5th May 2023.
  • Ebisch I, Farris D, Lazaro Pacheco D, Holsgrove T. (2023) Development of an integrated spine biomechanics framework combining in-vivo, in-silico and in-vitro methods, 4th International Workshop on Spine Loading and Deformation, Berlin, Germany, 5th - 7th Jul 2023.
  • Rivera Tapia D, Meakin J, Holsgrove T. (2023) A model of intervertebral disc degeneration using combined cyclic overloading and enzyme digestion, 4th International Workshop on Spine Loading and Deformation, Berlin, Germany, 5th - 7th Jul 2023.
  • Lazaro Pacheco D, Holsgrove T. (2023) Load Informed Kinematic Evaluation (LIKE) protocols for the simulation of daily activities in the intervertebral disc (IVD), 4th International Workshop on Spine Loading and Deformation, Berlin, Germany, 5th - 7th Jul 2023.
  • Lazaro-Pacheco D, Mohseni M, Rudd S, Cooper-White J, Holsgrove TP. (2023) The role of biomechanical factors in models of intervertebral disc degeneration across multiple length scales, APL Bioengineering, volume 7, no. 2, DOI:10.1063/5.0137698. [PDF]

2022

  • Lazaro Pacheco D, Yan Ho S, Holsgrove T. (2022) The development of complex physiological loading profiles for the study of the intervertebral disc, ORS PSRS 6th International Spine Research Symposium, Skytop, Pa, Usa, 6th - 10th Nov 2022.
  • Lazaro Pacheco D, Holsgrove T. (2022) The development of a six-axis bioreactor for the application of complex physiological loading, 9th World Congress of Biomechanics, Taipei, Taiwan, 10th - 14th Jul 2022.
  • Lazaro Pacheco D, Holsgrove T. (2022) Evaluation of cell viability in low cell density intervertebral disc (IVD) tissue: tips and technical notes, World Congress of Orthopaedic Research, Edinburgh, Uk, 7th - 9th Sep 2022.
  • Rivera Tapia ED, Meakin JR, Holsgrove TP. (2022) In-vitro models of disc degeneration – A review of methods and clinical relevance, Journal of Biomechanics, volume 142, pages 111260-111260, article no. 111260, DOI:10.1016/j.jbiomech.2022.111260. [PDF]

2021

  • Ward J, Ruell G, Holsgrove T. (2021) Racing in the street – Whole-body vibration during road cycling and the effect of different equipment choices to minimise it, XXVIII Congress of the International Society of Biomechanics, Stockholm, Sweden, 25th - 29th Jul 2021.
  • Rivera Tapia D, Meakin J, Holsgrove T. (2021) In-vitro modelling of the human intervertebral disc degneneration, 26th Congress of the European Society of Biomechanics, Milan, Italy, 11th - 14th Jul 2021.
  • Edwards PI, Holsgrove TP. (2021) Thunder road - whole-body vibration during road cycling, and the effect of different seatpost designs to minimise it, J Sports Sci, volume 39, no. 5, pages 489-495, DOI:10.1080/02640414.2020.1829361. [PDF]

2020

2019

  • Bailey M, Alunni-Cardinali M, Correa N, Caponi S, Holsgrove T, Barr H, Stone N, Winlove CP, Fioretto D, Palombo F. (2019) Brillouin-derived viscoelastic parameters of hydrogel tissue models, DOI:10.48550/arxiv.1912.08292.
  • Williams E, Cheung K, Clarke A, Holsgrove T. (2019) Validation of a low-cost system for 3D spinal assessment in spine clinics, British Scoliosis Society (BSS) 2019, Cardiff, Uk, 21st - 22nd Nov 2019.
  • Davies R, Shyng Y, McCutchion P, Holsgrove T, Ghita O. (2019) PEEK laser sintered intervertebral lumbar cages: process and properties, 4th International PEEK Meeting, Washington Dc, Usa,, 25th - 26th Apr 2019, https://biomed.drexel.edu/peek/conferences/publication-files/2019-peek-program.pdf.
  • Holsgrove T. (2019) Beyond Preload -The Replication of Six-axis In-Vivo Load Data using a Spine Simulator, 3rd International Workshop on Spine Loading and Deformation, Berlin, Germany, 4th - 6th Jul 2019.
  • Rivera Tapia D, Meakin J, Holsgrove T. (2019) In-Vitro Perspective into Micro-structural Degeneration of the Intervertebral Disc: a Biomechanical Approach, 3rd International Workshop on Spine Loading and Deformation, Berlin, Germany, 4th - 6th Jul 2019.
  • Silvestros P, Preatoni E, Gill HS, Gheduzzi S, Hernandez BA, Holsgrove TP, Cazzola D. (2019) Musculoskeletal modelling of the human cervical spine for the investigation of injury mechanisms during axial impacts, PLoS One, volume 14, no. 5, DOI:10.1371/journal.pone.0216663. [PDF]

2018

  • Bailey M, Correa N, Carinali MA, Caponi S, Holsgrove TP, Winlove CP, Fioretto D, Palombo F. (2018) Brillouin microscopy to probe the micromechanics of tissue phantoms, Physics and Biological Systems 2018, Gif-sur-yvette, France, 22nd - 24th Oct 2018.
  • Rivera Tapia ED, Meakin JR, Holsgrove TP. (2018) A macro- and micro-scale investigation into degenerative mechanisms of the intervertebral disc, 14th Annual Bath Biomechanics Symposium, Bath, Uk, 17th - 17th Sep 2018.
  • Silvestros P, Preatoni E, Gill HS, Gheduzzi S, Hernandez BA, Holsgrove TP, Cazzola D. (2018) Development of a musculoskeletal cervical spine model for the use in biomechanics analysis of axial impacts, 14th Annual Bath Biomechanics Symposium, Bath, Uk, 17th - 17th Sep 2018.
  • Bailey M, Correa N, Cardinali A, Caponi S, Holsgrove TP, Winlove CP, Fioretto D, Palombo F. (2018) Micromechanical properties of tissue phantoms probed by Brillouin microscopy, Advances in Brillouin Light Scattering & BioBrillouin Meeting, Perugia, Italy, 11th - 15th Sep 2018.
  • Silvestros P, Preatoni E, Gill HS, Gheduzzi S, Hernandez BA, Holsgrove TP, Cazzola D. (2018) Estimation of cervical spine internal loads with the use of validated bushing elements for sport collisions. Application in the analysis of head impacts in rugby contact events, 8th World Congress of Biomechanics, Dublin, Ireland, 8th - 12th Jul 2018.
  • Holsgrove TP, Amin DB, Pascual SR, Ding B, Welch WC, Gheduzzi S, Miles AW, Winkelstein BA, Costi JJ. (2018) The equivalence of multi-axis spine systems: Recommended stiffness limits using a standardized testing protocol, Journal of Biomechanics, volume 70, pages 59-66, DOI:10.1016/j.jbiomech.2017.09.010. [PDF]

2017

2016

  • Amin D, Holsgrove TP, Pascual SR, Ding D, Welch WC, Winkelstein BA, Gheduzzi S, Miles AW, Costi JJ. (2016) Standardized comparison testing of multi-axis spine simulators, Australian & New Zealand Orthopaedic Reseach Society Annual Conference.
  • Cazzola D, Holsgrove TP, Preatoni E, Gill HS, Trewartha G. (2016) MASI: a novel Musculoskeletal model for the Analysis of Spinal Injuries, Biomechanics and Neural Control of Movement.
  • Holsgrove TP, Jaumard NV, Zhu N, Stiansen NS, Welch WC, Winkelstein BA. (2016) Upper Cervical Spine Loading Simulating Low-Speed Collisions Significantly Increases Facet Strains Compared To Equivalent Quasistatic Loading, Summer Biomechanics, Bioengineering and Biotransport Conference.
  • Holsgrove TP, Zeeman ME, Welch WC, Winkelstein BA. (2016) The Resonance of the Thoracic Spine Under Whole Body Vibration is Non-Linear & Depends on Acceleration: An In Vivo Study Using a Rat Model, Summer Biomechanics, Bioengineering and Biotransport Conference.
  • Holsgrove TP, Jaumard NV, Zhu N, Stiansen NS, Welch WC, Winkelstein BA. (2016) Upper Cervical Spine Loading Simulating a Dynamic Low-Speed Collision Significantly Increases the Risk of Pain Compared to Quasi-Static Loading With Equivalent Neck Kinematics, Journal of Biomechanical Engineering, volume 138, no. 12, DOI:10.1115/1.4034707. [PDF]
  • Cazzola D, Stone B, Holsgrove TP, Trewartha G, Preatoni E. (2016) Spinal muscle activity in simulated rugby union scrummaging is affected by different engagement conditions, Scandinavian Journal of Medicine and Science in Sports, volume 26, no. 4, pages 432-440, DOI:10.1111/sms.12446.

2015

2014

  • Avis D, Wright S, Forder J, Miles AW, Holsgrove TP. (2014) Volar locking plates for distal radius fractures - a biomechanical study investigating optimal locking screw trajectory, British Orthopaedic Research Society Annual Meeting 2014.
  • Cazzola D, Holsgrove TP, Preatoni E, Stokes KA, Gheduzzi S, Miles AW, Gill HS, Trewartha G. (2014) A novel cervical spine (head/neck) musculoskeletal model for dynamic load analysis during rugby scrummaging, 7th World Congress of Biomechanics.
  • Gosiewski J, Holsgrove TP, Gill HS. (2014) Comparison of torque resistance between three fractured neck of femur fixation devices, British Hip Society Annual Meeting 2014.
  • Gosiewski J, Holsgrove TP, Gill HS. (2014) Experimental comparison of the torsional resistance between three proximal femur fracture fixation devices, Orthopaedic Research Society Annual Meeting.
  • Holsgrove TP, Cazzola D, Gheduzzi S, Miles AW, Preatoni E, Stokes KA, Trewartha G, Gill HS. (2014) The development and validation of specimen-specific finite element models of the spine to investigate sporting injury mechanisms, 7th World Congress of Biomechanics.
  • Stone B, Cazzola D, McGuigan MP, Holsgrove TP, Gill HS, Gheduzzi S, Miles AW, Stokes KA, Trewartha G, Preatoni E. (2014) Spinal muscle activity in simulated rugby union scrummaging is affected by different engagement conditions, Bath Biomechanics Symposium 2014.
  • Wright SJ, Forder J, Holsgrove TP, Miles AW. (2014) The effect of implanting a revision tibial knee component on the surface strain of the tibia: an in-vitro analysis using digital image correlation, 7th World Congress of Biomechanics.
  • Holsgrove TP, Gheduzzi S, Gill HS, Miles AW. (2014) The development of a dynamic, six-axis spine simulator, Spine Journal, volume 14, no. 7, pages 1308-1317, DOI:10.1016/j.spinee.2013.11.045.

2013

  • Holsgrove TP, Gheduzzi S, Miles AW. (2013) Pre-clinical performance testing of lumbar disc replacements, Bath Biomechanics Symposium 2013.
  • Holsgrove TP, Pentlow A, Miles AW. (2013) An in-vitro investigation of the shear strength of cement on cement mantles, 8th Combined Meeting of Orthopaedic Research Societies.
  • Holsgrove TP, Petheram TG, Miles AW, Timperley AJ. (2013) Distal stem features improve the torsional resistance of long-stem cemented revision hip stems: An in vitro biomechanical study, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, volume 227, no. 5, pages 503-509, DOI:10.1177/0954411913476616.
  • Cowan D, Smith M, Gardiner V, Horwood P, Morris C, Holsgrove T, Mayhew T, Long D, Hillman M. (2013) Mechanical and electromechanical devices, Clinical Engineering, Academic Press, 407-431.

2012

  • Holsgrove TP, Gheduzzi S, Miles AW. (2012) Dynamic comparison of porcine lumbar specimens with intact discs and disc replacements, 20th Annual Meeting of the European Orthopaedic Research Society.
  • Holsgrove TP, Petheram TG, Miles AW, Timperley AJ. (2012) An in-vitro biomechanical study of the torsional resistance of cemented polished femoral revision stems with distal stem features, British Orthopaedic Research Society Annual Meeting 2012.
  • Schmotzer H, Gheduzzi S, Holsgrove TP, Miles AW. (2012) Biologic fixation - a systematic approach, Material And Surface Technology for Implants 2012.

2010

  • Holsgrove TP, Gheduzzi S, Miles AW. (2010) The spinal countdown: a new multi-axis, in-vitro test method for disc arthroplasty devices, Bath Biomechanics Symposium 2010.

2007

  • Mak SY, Holsgrove TP, Miles AW. (2007) In-vitro study of influence of impaction energy on medial strain distribution in the femur during impaction grafting, Orthopaedic Research Society Annual Meeting.
  • Mak SY, Holsgrove TP, Miles AW. (2007) In-vitro study of medial strain distribution in the femur during impaction grafting, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, volume 221, no. 6, pages 613-619, DOI:10.1243/09544119JEIM220.

2006

  • Mak SY, Holsgrove TP, Miles AW. (2006) In vitro study of medial strain distribution in the femur during impaction grafting, Royal Academy of Engineering Futures Meeting 2006.

Patents

  • Percival A, Dekoninck EA, Miles AW, Holsgrove TP. Maternity mattress for supporting e.g. abdomen of pregnant woman, has support section in deformable state enabling its shape to adapt to shape and size of abdomen, and in non-deformable state supporting abdomen, Patent Number: WO2007128967-A3, 2007.

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