Overview

Academic Profile

Dr Junning Chen is a senior lecturer in Biomechanics, with primary research interests in pathological changes of tissue structures and functionality, including osteoarthritis and bone resorption. The research programme combines multiscale bio-tissue imaging techniques (e.g. microCT, Confocal Laser Scanning Microscopy, Scanning Electron Microscopy, Synchrotron x-ray Scattering, etc.) and numerical techniques (e.g. reserve engineering modelling, finite element analysis, dynamic modelling, etc.), to explore the effects of mechanical factors on microscopic tissue response and nanoscopic cellular and extracellular matrix responses under healthy, pathological and clinically treated conditions. The knowledge gained from this combined ex-vivo and in-silico approaches will be further applied in developing new biomaterial/structure through morphological optimisation, advanced prototyping (CAD-CAM and 3D printing) and in-vivo evaluation. Currently, the ongoing projects include

1) Residual Ridge Resorption of Mandible induced by Denture Wearing

2) Ultrastructurral and Mechanical Changes in Cartilage Ageing and Degeneration

3) Interface Structure and Biomechanics at the Calvarial Sutures in Skull

Education

2017          Alexander von Humboldt Fellowship, Max Planck Institute of Colloids and Interfaces

2015-2017 Postdoctoral Fellowship funded by German Research Council, Charité – Universitätsmedizin Berlin

2011-2015 PhD, Biomedical Engineering, The University of Sydney

2006-2010 BENG (First Class Hon), Biomedical Engineering, The University of Sydney

Research Grants

EPSRC Core Equipment Award EBOC (PI: Neil Gow) EP/V034251/1, 2020-2022, £632,086

(PI) EPSRC New Investigator Award EP/T008059/1, 2020-2022, £248,925

(PI) EPSRC Doctoral Training Partnershp, 2019-2021, £77k

(PI) ImagingBioPro Proof of Concept Awards, 2020-2021, £23k

(PI) OATech+ Network Biomechanics Pump-Priming Fund, 2019-2020, £10k

Position Opening

Both domestic and international students are welcome to apply for their MSc/PhD study with Dr Junning Chen, and available funding opportunities can be found through the University Funding Database or through their individual national funding agencies. 

More Information about Junning

     ResearchGate

     Goolge Scholar

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Publications

_{Copyright Notice: Any articles made available for download are for personal use only. Any other use requires prior permission of the author and the copyright holder.}

| 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | Patents |

2023

• Tian J. (2023) Biomechanics of a Vibro-Impact Capsule Robot Self-Propelling in the Lower Gastrointestinal Tract.
• Nebbiolo E. (2023) Multiple Imaging Modalities for Investigating Soft Hard Tissue Interfaces.
• Zhong J, Shibata Y, Wu C, Watanabe C, Chen J, Zheng K, Hu J, Swain MV, Li Q. (2023) Functional non-uniformity of periodontal ligaments tunes mechanobiological stimuli across soft- and hard-tissue interfaces, Acta Biomater, volume 170, pages 240-249, DOI:10.1016/j.actbio.2023.08.047. [PDF]

2022

• Hu J, Gundry M, Zheng K, Zhong J, Hourigan P, Meakin JR, Winlove CP, Toms AD, Knapp KM, Chen J. (2022) The biomechanics of metaphyseal cone augmentation in revision knee replacement, J Mech Behav Biomed Mater, volume 131, DOI:10.1016/j.jmbbm.2022.105233. [PDF]
• Zheng K, Yoda N, Chen J, Liao Z, Zhong J, Wu C, Wan B, Koyama S, Sasaki K, Peck C. (2022) Bone remodeling following mandibular reconstruction using fibula free flap, Journal of Biomechanics, volume 133, pages 110968-110968, article no. 110968, DOI:10.1016/j.jbiomech.2022.110968. [PDF]
• Assiri R, Knapp K, Fulford J, Chen J. (2022) Correlation of the quantitative methods for the measurement of bone uptake and plasma clearance of 18F-NaF using positron emission tomography. Systematic review and meta-analysis, Eur J Radiol, volume 146, DOI:10.1016/j.ejrad.2021.110081. [PDF]

2021

• Sherlock BE, Chen J, Mansfield JC, Green E, Winlove CP. (2021) Biophotonic tools for probing extracellular matrix mechanics, Matrix Biology Plus, volume 12, DOI:10.1016/j.mbplus.2021.100093.
• Zhong J, Pierantoni M, Weinkamer R, Brumfeld V, Zheng K, Chen J, Swain MV, Weiner S, Li Q. (2021) Microstructural heterogeneity of the collagenous network in the loaded and unloaded periodontal ligament and its biomechanical implications, J Struct Biol, volume 213, no. 3, DOI:10.1016/j.jsb.2021.107772. [PDF]
• Tian J, Liu Y, Chen J, Guo B, Prasad S. (2021) Finite element analysis of a self-propelled capsule robot moving in the small intestine, International Journal of Mechanical Sciences, volume 206, pages 106621-106621, article no. 106621, DOI:10.1016/j.ijmecsci.2021.106621. [PDF]

2020

• Entezari A, Liu NC, Roohani I, Zhang Z, Chen J, Sarrafpour B, Zoellner H, Behi M, Zreiqat H, Li Q. (2020) On design for additive manufacturing (DAM) parameter and its effects on biomechanical properties of 3D printed ceramic scaffolds, Materials Today Communications, volume 23, DOI:10.1016/j.mtcomm.2020.101065.
• Jayasankar AK, Seidel R, Hosny A, Weaver JC, Fratzl P, Chen J, Dean MN. (2020) Multi-scale modeling and mechanical performance characterization of stingray skeleton-inspired tessellations, Journal of the Mechanics and Physics of Solids, volume 138, pages 103906-103906, article no. 103906, DOI:10.1016/j.jmps.2020.103906. [PDF]
• Lu C, Hou S, Zhang Z, Chen J, Li Q, Han X. (2020) The mystery of coconut overturns the crashworthiness design of composite materials, International Journal of Mechanical Sciences, volume 168, DOI:10.1016/j.ijmecsci.2019.105244.
• Zhong J, Guazzato M, Chen J, Zhang Z, Sun G, Huo X, Liu X, Ahmad R, Li Q. (2020) Effect of different implant configurations on biomechanical behavior of full-arch implant-supported mandibular monolithic zirconia fixed prostheses, Journal of the Mechanical Behavior of Biomedical Materials, volume 102, DOI:10.1016/j.jmbbm.2019.103490.
• Zheng K, Yoda N, Chen J, Liao Z, Zhong J, Koyama S, Peck C, Swain M, Sasaki K, Li Q. (2020) Effects of buccal thickness augmentation on bone remodeling after maxillary anterior implantation, Biomech Model Mechanobiol, volume 19, no. 1, pages 133-145, DOI:10.1007/s10237-019-01200-x. [PDF]

2019

• van Tol AF, Roschger A, Repp F, Chen J, Roschger P, Berzlanovich A, Gruber GM, Fratzl P, Weinkamer R. (2019) Network architecture strongly influences the fluid flow pattern through the lacunocanalicular network in human osteons, Biomechanics and Modeling in Mechanobiology, volume 19, no. 3, pages 823-840, DOI:10.1007/s10237-019-01250-1. [PDF]
• Roschger A, Roschger P, Wagermaier W, Chen J, van Tol AF, Repp F, Blouin S, Berzlanovich A, Gruber GM, Klaushofer K. (2019) The contribution of the pericanalicular matrix to mineral content in human osteonal bone, Bone, volume 123, pages 76-85, DOI:10.1016/j.bone.2019.03.018. [PDF]
• Zheng K, Liao Z, Yoda N, Fang J, Chen J, Zhang Z, Zhong J, Peck C, Sasaki K, Swain MV. (2019) Investigation on masticatory muscular functionality following oral reconstruction – An inverse identification approach, Journal of Biomechanics, volume 90, pages 1-8, DOI:10.1016/j.jbiomech.2019.04.007.
• Zhong J, Chen J, Weinkamer R, Darendeliler MA, Swain MV, Sue A, Zheng K, Li Q. (2019) In vivo effects of different orthodontic loading on root resorption and correlation with mechanobiological stimulus in periodontal ligament, Journal of the Royal Society Interface, volume 16, no. 154, DOI:10.1098/rsif.2019.0108.

2018

• Yoda N, Zheng K, Chen J, Liao Z, Koyama S, Peck C, Swain M, Sasaki K, Li Q. (2018) Biomechanical analysis of bone remodeling following mandibular reconstruction using fibula free flap, Medical Engineering and Physics, volume 56, DOI:10.1016/j.medengphy.2018.03.008.

2017

• Yoda N, Zheng K, Chen J, Li W, Swain M, Sasaki K, Li Q. (2017) Bone morphological effects on post-implantation remodeling of maxillary anterior buccal bone: A clinical and biomechanical study, Journal of Prosthodontic Research, volume 61, no. 4, pages 393-402, DOI:10.1016/j.jpor.2016.12.010. [PDF]
• Liao Z, Elekdag-Turk S, Turk T, Grove J, Dalci O, Chen J, Zheng K, Ali Darendeliler M, Swain M, Li Q. (2017) Computational and clinical investigation on the role of mechanical vibration on orthodontic tooth movement, Journal of Biomechanics, volume 60, pages 57-64, DOI:10.1016/j.jbiomech.2017.06.012. [PDF]
• Chen J, Chen L, Chang CC, Zhang Z, Li W, Swain MV, Li Q. (2017) Micro-CT based modelling for characterising injection-moulded porous titanium implants, International Journal for Numerical Methods in Biomedical Engineering, volume 33, no. 1, DOI:10.1002/cnm.2779.
• Liao Z, Yoda N, Chen J, Zheng K, Sasaki K, Swain MV, Li Q. (2017) Simulation of multi-stage nonlinear bone remodeling induced by fixed partial dentures of different configurations: a comparative clinical and numerical study, Biomechanics and Modeling in Mechanobiology, volume 16, no. 2, pages 411-423, DOI:10.1007/s10237-016-0826-x.
• Zheng K, Scholes CJ, Chen J, Parker D, Li Q. (2017) Multiobjective optimization of cartilage stress for non-invasive, patient-specific recommendations of high tibial osteotomy correction angle – a novel method to investigate alignment correction, Medical Engineering and Physics, volume 42, pages 26-34, DOI:10.1016/j.medengphy.2016.11.013.

2016

• Li W, Chen J, Rungsiyakull C, Swain MV, Li Q. (2016) Multiscale remodelling and topographical optimisation for porous implant surface morphology design, Springer Series in Biomaterials Science and Engineering, 71-105, DOI:10.1007/978-3-662-53574-5_3.
• Yoda N, Liao ZP, Chen JN, Sasaki K, Li Q. (2016) The Biomechanical Responses of Mandibular Bone Installed with Fixed Partial Denture, Applied Mechanics and Materials, volume 846, pages 276-281, DOI:10.4028/www.scientific.net/amm.846.276. [PDF]
• Li W, Chen J, Rungsiyakull C, Swain MV, Li Q. (2016) Multiscale remodelling and topographical optimisation for porous implant surface morphology design, Springer Series in Biomaterials Science and Engineering, 71-105, DOI:10.1007/978-3-662-53574-5_3.
• Zhang Z, Chen J, Li E, Li W, Swain M, Li Q. (2016) Topological design of all-ceramic dental bridges for enhancing fracture resistance, International Journal for Numerical Methods in Biomedical Engineering, volume 32, no. 6, pages 1-13, DOI:10.1002/cnm.2749.
• Chen J, Suenaga H, Hogg M, Li W, Swain M, Li Q. (2016) Determination of oral mucosal Poisson’s ratio and coefficient of friction from in-vivo contact pressure measurements, Computer Methods in Biomechanics and Biomedical Engineering, volume 19, no. 4, pages 357-365, DOI:10.1080/10255842.2015.1028925.
• Suenaga H, Chen J, Yamaguchi K, Sugazaki M, Li W, Swain M, Li Q, Sasaki K. (2016) Bone metabolism induced by denture insertion in positron emission tomography, Journal of Oral Rehabilitation, volume 43, no. 3, pages 198-204, DOI:10.1111/joor.12356.
• Li E, Chen J, Zhang Z, Fang J, Liu GR, Li Q. (2016) Smoothed finite element method for analysis of multi-layered systems-Applications in biomaterials, Computers and Structures, volume 168, pages 16-29, DOI:10.1016/j.compstruc.2016.02.003.
• Fang J, Gao Y, An X, Sun G, Chen J, Li Q. (2016) Design of transversely-graded foam and wall thickness structures for crashworthiness criteria, Composites Part B: Engineering, volume 92, pages 338-349, DOI:10.1016/j.compositesb.2016.02.006.
• Liao Z, Chen J, Li W, Darendeliler MA, Swain M, Li Q. (2016) Biomechanical investigation into the role of the periodontal ligament in optimising orthodontic force: A finite element case study, Archives of Oral Biology, volume 66, pages 98-107, DOI:10.1016/j.archoralbio.2016.02.012.
• Yoda N, Liao Z, Chen J, Sasaki K, Swain M, Li Q. (2016) Role of implant configurations supporting three-unit fixed partial denture on mandibular bone response: biological-data-based finite element study, Journal of oral rehabilitation, volume 43, no. 9, pages 692-701, DOI:10.1111/joor.12411.
• Kobari H, Yoda N, Chen J, Kawata T, Sasaki K. (2016) An in vivo study on load distribution in different implant configurations for supporting fixed partial dentures, International Journal of Oral and Maxillofacial Implants, volume 31, no. 5, pages 1049-1057, DOI:10.11607/jomi.4554.
• Ahmad R, Abu-Hassan MI, Chen J, Li Q, Swain MV. (2016) The relationship of mandibular morphology with residual ridge resorption associated with implant-retained overdentures, International Journal of Prosthodontics, volume 29, no. 6, pages 573-580, DOI:10.11607/ijp.4726.

2015

• Entezari A, Zhang Z, Chen J, Li Q. (2015) Optimization of bone tissue scaffolds fabricated by robocasting technique, 11th World Congress on Structural and Multidisciplinary Optimisation, Sydney, 7th - 12th Jun 2015, Journal Structural and Multidisciplinary Optimization, volume 51, no. 3, pages 799-800, DOI:10.1007/s00158-014-1172-1.
• Chen J, Ahmad R, Suenaga H, Li W, Swain M, Li Q. (2015) A comparative study on complete and implant retained denture treatments - A biomechanics perspective, Journal of Biomechanics, volume 48, no. 3, pages 512-519, DOI:10.1016/j.jbiomech.2014.11.043.
• Rungsiyakull C, Chen J, Rungsiyakull P, Li W, Swain M, Li Q. (2015) Bone’s responses to different designs of implant-supported fixed partial dentures, Biomechanics and Modeling in Mechanobiology, volume 14, no. 2, pages 403-411, DOI:10.1007/s10237-014-0612-6.
• Suenaga H, Chen J, Yamaguchi K, Li W, Sasaki K, Swain M, Li Q. (2015) Mechanobiological bone reaction quantified by positron emission tomography, Journal of Dental Research, volume 94, no. 5, pages 738-744, DOI:10.1177/0022034515573271.
• Chen J, Ahmad R, Suenaga H, Li W, Sasaki K, Swain M, Li Q. (2015) Shape optimization for additive manufacturing of removable partial dentures - A new paradigm for prosthetic CAD/CAM, PLoS ONE, volume 10, no. 7, DOI:10.1371/journal.pone.0132552.
• Chen J, Ahmad R, Li W, Swain M, Li Q. (2015) Biomechanics of oral mucosa, Journal of the Royal Society Interface, volume 12, no. 109, DOI:10.1098/rsif.2015.0325.
• Liao Z, Chen J, Zhang Z, Li W, Swain M, Li Q. (2015) Computational modeling of dynamic behaviors of human teeth, Journal of Biomechanics, volume 48, no. 16, pages 4214-4220, DOI:10.1016/j.jbiomech.2015.10.019.
• Ahmad R, Chen J, Abu-Hassan MI, Li Q, Swain MV. (2015) Investigation of mucosa-induced residual ridge resorption under implant-retained overdentures and complete dentures in the mandible, International Journal of Oral and Maxillofacial Implants, volume 30, no. 3, pages 657-666, DOI:10.11607/jomi.3844.

2014

• Li W, Lin D, Chen J, Zhang Z, Liao Z, Swain M, Li Q. (2014) Role of Mechanical Stimuli in Oral Implantation, Journal of Biosciences and Medicines, volume 02, no. 04, pages 63-68, DOI:10.4236/jbm.2014.24010. [PDF]
• Chen J, Li W, Swain MV, Ali Darendeliler M, Li Q. (2014) A periodontal ligament driven remodeling algorithm for orthodontic tooth movement, Journal of Biomechanics, volume 47, no. 7, pages 1689-1695, DOI:10.1016/j.jbiomech.2014.02.030.
• Ioannidis CC, Dabirrahmani D, Li Q, Zhang Z, Chen J, Appleyard R. (2014) Impaction loads resulting in intraoperative periprosthetic femoral fracture: A finite element study, Applied Mechanics and Materials, volume 553, pages 299-304, DOI:10.4028/www.scientific.net/AMM.553.299.
• Chen J, Ahmad R, Swain MV, Li W, Suenaga H, Li Q. (2014) Comparing contact pressure induced by a conventional complete denture and an implant-retained overdenture, Applied Mechanics and Materials, volume 553, pages 384-389, DOI:10.4028/www.scientific.net/AMM.553.384.
• Suenaga H, Chen J, Li W, Yamaguchi K, Sasaki K, Li Q, Swain M. (2014) Validate mandible finite element model under removable partial denture (RPD) with in vivo pressure measurement, Applied Mechanics and Materials, volume 553, pages 322-326, DOI:10.4028/www.scientific.net/AMM.553.322.
• Zheng K, Chen J, Scholes C, Li Q. (2014) Magnetic resonance imaging (MRI) based finite element modeling for analyzing the influence of material properties on menisci responses, Applied Mechanics and Materials, volume 553, pages 305-309, DOI:10.4028/www.scientific.net/AMM.553.305.

2013

• Chen J, Chen L, Li W, Swain M, Li Q. (2013) Porous titanium implant and micro-CT based characterization of sub-surface morphology, 8th Pacific Rim International Congress on Advanced Materials and Processing 2013, PRICM 8, volume 2, pages 1579-1586, DOI:10.1007/978-3-319-48764-9_198.
• Chen J, Rungsiyakull C, Li W, Chen Y, Swain M, Li Q. (2013) Multiscale design of surface morphological gradient for osseointegration, Journal of the Mechanical Behavior of Biomedical Materials, volume 20, pages 387-397, DOI:10.1016/j.jmbbm.2012.08.019.
• Cadman J, Chang CC, Chen J, Chen Y, Zhou S, Li W, Li Q. (2013) Bioinspired lightweight cellular materials - Understanding effects of natural variation on mechanical properties, Materials Science and Engineering C, volume 33, no. 6, pages 3146-3152, DOI:10.1016/j.msec.2013.03.031.
• Cadman J, Chang C-C, Chen J, Chen Y, Zhou S, Li W, Li Q. (2013) Bioinspired lightweight cellular materials--understanding effects of natural variation on mechanical properties, Mater Sci Eng C Mater Biol Appl, volume 33, no. 6, pages 3146-3152, DOI:10.1016/j.msec.2013.03.031. [PDF]

Patents

• Virr A, Kao D, Fu X, Snow JM, Chen J. Respirator, Patent Number: US20120174922A1, 2016.
• Virr A, Bath AR, Row NJ, Kao D, Hill PK, Earl NA, Verma H, Chen J. Humidifier with a Water Tub within a Pressurized Chamber, Patent Number: US8631789B2, 2014.

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