The Biomedical Engineering research group is an interdisciplinary collaboration between the Departments of Physics and Engineering. The group uses computational and experimental techniques to provide greater understanding of the fundamental properties of biological tissue, how injury and degeneration occur in the musculoskeletal system, and it works closely with the College of Medicine and Health and the Royal Devon & Exeter Hospital to improve medical treatment through the optimisation of therapies, medical devices, and surgical practice.
This research focus includes the investigation of joint loading, injury and degeneration, and the evaluation of medical devices. The group has a strong interest in spine biomechanics, particularly in relation to individual posture and loading, spinal injuries due to dynamic loading such those experienced during sports such as rugby, and the mechanisms of and treatments for disc degeneration.
Additional focuses are on the development and evaluation of medical devices for total hip and knee replacements, and dental implants.
The group has interests in both the characterisation of biological tissues, and the development of biomaterials for medical devices. This includes research into the structure of bone and the use of additive manufactured PEEK and auxetic materials for biomedical applications.
We are investigating the relationships between the structures of tissues and their micromechanics, and the biophysics of the fibrous proteins. Currently much of our work is directed towards identification of early changes associated with osteoarthritis and on the nature of the bone:soft tissue interface. Our work on cellular biomechanics is directed towards understanding the role of the pericellular matrix in mechanotransduction in cartilage.
We have developed a range of methodologies to characterise the mechanical and electrical properties of the plasma membranes of intact cells and model systems such as giant vesicles and Langmuir monolayers. These allow us to adopt an integrative approach to problems such as the role of membrane lipids in cellular invasion by pore-forming toxins and the effects of oxidative stress in chronic conditions such as diabetes and in acute inflammation on membrane function.
|Dr Jude Meakin||Spinal biomechanics|
|Professor Peter Winlove||Extracellular matrix and cell membrane biophysics|
|Dr Timothy Holsgrove||Orthopaedic biomechanics, spinal injury and degeneration|
|Dr Junning Chen||Biomechanics and computational simulation|
|Professor Francesca Palombo||Brillouin microscopy in biomedicine|
|Dr Peter Petrov||Membranes, soft matter biophysics|
|Dr Mohammad Akrami||Musculoskeletal biomechanics|
|Dr Corrina Cory||Injury biomechanics|
|Professor Akbar Javadi||Computational biomechanics and orthotics|
|Professor Chris Smith||Advanced simulation tools for solid mechanics|
|Professor Philippe Young||Image processing and computational simulation|
|Professor Oana Ghita||Additive layer manufacturing|
|Professor Aleksandar Pavic||Human motion and biomechanics|
|Professor Ken Evans||Auxetics and biomaterials|
|Professor John Timperley||Orthopaedics (hips)|
|Professor Christina Doyle||Biomaterials, tissue regeneration, device development and regulation|
|Dr Ben Sherlock||Translational biophotonics and customised optical imaging systems|
Biomedical Engineering Research Laboratory
- Tissue preparation and storage (-20°C and -80°C)
- Esco Airstream Class II biological safety cabinet
- Esco CelCulture CO2 incubator
- Priorclave Compact 40 autoclave
- Ductaire 700 fume hood
- Triple Red Geno type 2 water purification system
- Instron Elelctropuls E10000 dynamic testing machine
- Qualisys Miqus 6 camera motion capture system
- Fiso fibre-optic pressure transducers
- ADPM Opal wireless wearable sensors
- Scan IP+FE and Abaqus software for medical image processing and computational modelling